0:01 so this video is going to cover the pros
0:04 and cons I experienced with the switch
0:07 from ovisa senta and also what I'm
0:09 considering moving forward hi everyone
0:11 I'm Cliff and I have MS but first before
0:13 we get started here's a fun little fact
0:15 Germany has the highest rate of
0:17 diagnosed multiple sclerosis in the
0:20 world people really don't know why yet
0:21 though it could have something to do
0:23 with their
0:26 pretzels most importantly here I'm not a
0:28 doctor I'm not a clinician talk to your
0:30 doctor about all this stuff this is just
0:32 my experience and my perspective if you
0:34 are recently diagnosed and your doctor
0:36 has said it's time to make a decision
0:38 about which drug to take even though
0:41 this video is about someone who's been
0:44 on both drugs for almost 5 years I think
0:45 it's going to have a lot of valuable
0:48 information for you because looking back
0:49 I would have done things a little bit
0:51 differently when I started my drug
0:53 regimen for multiple sclerosis and we'll
0:55 talk about that so first off what's the
0:58 difference between okis and cassa well
1:00 there are a lot of differences
1:02 I think the biggest difference is the
1:06 delivery mechanism so with okis you go
1:09 into a clinic every six months and sit
1:11 there in an infusion chair they plug you
1:13 into an IV you have a clinical staff
1:16 there and you sit there from 4 to 6 to 7
1:18 hours while this stuff drips into your
1:22 system with centa it's basically a home
1:24 injection and if you get queasy at the
1:25 thought of doing your own
1:28 injections keep listening because I
1:30 really battled with that and I'll talk
1:32 about that later if you want to get kind
1:34 of nerdy with the science behind this
1:36 basically these two drugs block a cd20
1:37 protein here's a nice little
1:40 illustration on a scientific front that
1:42 Dr freehan allowed me to use thank you
1:45 Doctor both are CD monoclonal antibodies
1:47 meaning they target and deplete B cells
1:49 in the immune system thought to
1:52 contribute to Ms they do this in
1:54 slightly different ways but the end goal
1:57 is to Target the cd20 protein bind to it
1:59 and render it basically ineffective okay
2:01 so the administration of the drug is for
2:04 me was 7 hours with okris every 6 months
2:07 and it's about 5 seconds with cassa
2:11 every month so I started on okis in 2018
2:13 and what eventually ended up happening
2:15 is after 2 years I switched to cassa
2:17 because okis was not working for me and
2:19 what do I mean by okris not working for
2:21 me well it was working for me in
2:23 stopping the progression of disease but
2:25 all was not well in ois land and I'm
2:27 going to talk about the cons of my
2:29 experience with okis first of all the
2:31 lengthy Administration I don't like
2:33 sitting anywhere for 6 hours just not
2:35 comfortable sitting down so that was not
2:37 okay with also I just don't like needles
2:39 and IVs the prophylactic drug cocktail
2:43 which consisted of badril and Tylenol
2:46 and Zofran for the nausea plus two other
2:47 things I don't remember what they were I
2:49 think caused a lot of the side effects
2:51 the next day I mean you're unloading a
2:53 lot of crap in your system in one day
2:56 the crap Gap the crap Gap is basically
2:57 there's this time that after you get
2:59 your infusion where things seem to be
3:01 going swimming ly well and then it falls
3:03 off and you have to wait until your next
3:06 infusion for those things to resolve so
3:10 what I mean is my symptoms would really
3:14 be reduced during that first three
3:16 months remember this is a six month
3:17 infusion like you take it and then you
3:19 wait six months for the next one the
3:21 first three months were good the last
3:23 three months were terrible everything
3:26 came back and it was just miserable this
3:29 became a a constant I could set my watch
3:30 to it and and it's one of the main
3:32 reasons I started looking at other drugs
3:35 the side effects were pretty gnarly 3 or
3:39 4 days after the infusions just I just
3:41 felt crappy and like I said you're
3:42 putting a lot of drugs in your body in
3:45 one day the clinical scheduling may have
3:49 changed but back in 2018 2019 of course
3:52 covid started and getting into a clinic
3:55 um was just a hassle and uh which just
3:57 added another step to the process of
3:59 something I didn't want to do to begin
4:02 with all right let's talk about the
4:05 prosis Okay it definitely helped with
4:06 the symptoms for the first three months
4:09 of the infusion it definitely reduced
4:11 relapses um it definitely reduced
4:14 progression according to my
4:17 MRIs and uh the clinics had yummy snacks
4:20 and cozy lounge chairs so I mean the
4:21 drug was
4:23 effective I just don't know if it was
4:24 effective in reducing symptoms but they
4:26 never promised that they said they were
4:28 reducing progression and reducing
4:32 relapses so okis not bad but there's
4:34 better so then I moved on to cassa with
4:38 the idea that if I took cassa once a
4:40 month I'd have more regular dosing and I
4:42 wouldn't get the crap Gap because that
4:44 was my main complaint what are the cons
4:46 with cassa well finding a comfortable
4:48 injection site you know something that I
4:49 think everybody has to get used to I
4:52 initially ejected in my upper thigh like
4:54 they said on the brochures it was very
4:58 uncomfortable but I did find Place uh
5:00 around my abdomen that where's a little
5:01 bit of fat that I can inject into and I
5:03 really don't feel it so I'd say nine
5:06 times out of 10 is very tolerable at
5:09 this point you get better at it initial
5:12 dosing so initially you do one shot a
5:15 week for three weeks and then I think
5:16 you skip a month and then you start
5:18 doing your once a month thing that first
5:20 ramp up is a little much you're getting
5:23 used to a total lifestyle change where
5:24 you're now responsible for these drugs
5:26 and scheduling them yourself and doing
5:28 all that stuff and the side effects for
5:30 me were really gnarly after the first
5:33 few injections 3 days after I do my
5:35 injections I'm just not a very nice
5:36 person because I'm just very
5:37 uncomfortable but it fades quickly and
5:39 now as of the last two or three months
5:41 it has not been bad at all um I'm very
5:43 functional after my injection however
5:45 cassa in general just fatigues me a
5:48 little bit more I noticed um being
5:50 responsible for the drug well they ship
5:52 it right to your door you put it in your
5:54 refrigerator and it stays there
5:57 refrigerated until the day you take it
5:59 and you know for some people that's a
6:03 eight n $10,000 a month drug just having
6:05 it there in the refrigerator thinking
6:06 that someone could accidentally leave it
6:09 out or throw it away is uh you know it
6:12 definitely sits on my mind but I have a
6:13 special spot for in the refrigerator and
6:16 it's fine remembering to take it I'm
6:18 very OCD about my schedule stuff it's
6:21 not a problem for me but for someone
6:23 else that's not as OCD about their
6:25 schedule I think you know you take
6:27 something once a month um you better put
6:30 it in Google reminders because you're
6:32 going to forget the ramp up side effects
6:33 I talked a little bit about that my
6:36 first 3 to four months pretty rough for
6:38 the first 3 to 4 days after the
6:39 injections and then my body kind of got
6:41 used to it I think I don't know but it's
6:43 not nearly as bad anymore it's very
6:47 tolerable the pros of cempa well home
6:48 delivery right you're not scheduling
6:50 Clinic time which is awesome it
6:52 literally takes 5 Seconds to inject
6:54 which is awesome you have the rest of
6:55 your day you're not committing your day
6:57 to sitting in a clinic though eating the
6:59 cookies was kind of nice minimal side effects
7:00 effects
7:01 I've had and I put an aster next to that
7:03 because I think it changes for everybody
7:05 but after the fourth or fifth month for
7:07 me I'd have to say the side effects are
7:10 not bad not bad at all uh no
7:12 prophylactic cocktails I don't need to
7:14 take all those drugs like benad dril and
7:17 zofran and all that stuff prior to doing
7:18 the injection which is really nice
7:21 because I don't like taking that stuff
7:23 and so that's just one extra step I
7:24 don't have to remember to do and
7:25 something I don't have to be
7:27 uncomfortable about even though I hate
7:30 needles I hate IVs I hate all that stuff
7:32 it does get easier it getss easier to
7:33 give myself an injection every time and
7:36 now it's very easy but you know the
7:38 first time I did it it took me an hour
7:41 to convince myself so cassa wins out for
7:43 convenience and and not only that I
7:45 think my Ms feels a lot more manageable
7:47 at this point and I'm not experiencing
7:51 any crap gaps so that part's great I
7:53 hope you found this information helpful
7:54 please comment below if you have any
7:56 questions that I can answer again I'm
7:58 not a doctor I'm not a clinician I'm
8:00 just a random dude on YouTube with Ms
8:02 that's a patient and also takes
8:04 cinta click that subscribe if you don't
8:06 mind and hit that like button if you
8:08 enjoyed this stuff because I want to
8:09 make this channel a nice little
8:11 Community where we can share knowledge
8:13 and experiences not just around Ms but
8:16 life in general I appreciate you I'm
