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Vitamin D Therapy Explained by Dr. Cicero Coimbra | Benefits, Uses & Protocols

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[Music]

Dr. Ceero Coimbra earned his medical

degree from the federal university of

Rio Grande Doul in 1979 and holds

specialist degrees in internal medicine

and neurology. He completed a fellowship

in pediatric neurology at the Jackson

Memorial Hospital of the University of

Miami and completed post-doal training

at the University of

London. He was associate professor in

the department of neurology and

neurosurgery and is the founding

president of the institute for research

and treatment of autoimmunity in Brazil.

Dr. Dr. Coinbra's clinical work focuses

on neurodeenerative and autoimmune

diseases and he currently seeks to

deepen and share his knowledge about the

causes of the worldwide exponential rise

in the prevalence of autism spectrum

disorder and other neurodedevelopmental

disorders. Dr. Cobra is the founder of

the Kimbra protocol which uses high

therapeutic doses of vitamin D to treat

autoimmune diseases. This protocol is

now used in at least 13 countries by

over 200 doctors who have been trained

by Dr. Cobbra or other trained

physicians. The treatment of high doses

of vitamin D for autoimmune diseases was

developed based on the results of the

human genome project. These findings led

to the identification of polymorphisms

affecting the genes necessary for the

immunom modulatory effects of vitamin D

metabolites in patients with autoimmunity.

autoimmunity.

Individually adjusted high doses of

vitamin D were found to counteract the

resistance resulting from those polymorphic

polymorphic

changes. Patients from several countries

have greatly benefited from this

protocol. I welcome Dr. Kimber today to

tell us more about it and these amazing

benefits. How did you first become

interested in vitamin D as a neurologist

Okay.

Um, by the year 2000, I had a

uh my first appointment with a patient

with Parkinson's

disease and he had several spots of

italo in on his

forehead. At that time I was interested

in the therapeutic approaches that could

enhance the synthesis of neurotrophic

factors in brain tissue as these factors

could prevent neuron neuronal degeneration.

degeneration.

So by that time I had read about uh

um reports on the stimulatory effects of

vitamin D

um on the production of of neurotro

neurotro neurotrophic factors.

So trying to help that patient

neurologically, I prescribed the 10,000

units of vitamin D in the form of

choleicoliferol to see if his

parkinsonian symptoms uh could be better

controlled. That daily dose was already

established as no adverse effect

level. When he came back six months

later, his neurological state was about

the same. But the vitiligo spots had

almost completely

disappeared. Then I searched the medical

literature and found about 300 uh

scientific papers discuss discussing the

importance of vitamin D for the immune

system. Today we have more than half a

million papers on that

subject. That was when I started

prescribing 10,000 units of vitamin D

daily for patients with autoimmune

disorders. not only MS but mainly for MS

patients because as you know I'm a

neurologist and I was amazed the results

were impressive just by giving them

10,000 units of vitamin D

uh at that time I found a paper

published in 1986

uh by Goldberg and core workers from Boston

Boston

uh reporting a reduced frequency of

relapses in MS patients taking about

5,000 units of vitamin D in the form of

oil. Uh and they uh demonstrated it was

just a a simple

um research. They they compared the um

the frequency of relapses before giving

them about 10,000 5,000 units of vitamin

D and after uh during this uh during the

period when they were receiving that

amount of vitamin D and they found a

reduced uh frequency of

relapses. So that was the beginning of everything.

everything.

So this first presentation shows that

vitamin D is essentially syn synthesized

in our skin when we are exposed to UVB

light. This occurs when the sun is high

enough to produce a shadow that is not

larger than our it's not larger than our station.

station.

If you are living in big cities working

in a confined

environment and are not properly

supplemented with vitamin D, then you

are definitely vitamin D

deficient. Vitamin D is actually a

precursor of a steroid or hormone and

can been turned into its correspondent

uh active hormone in several of our

cells, not only in kidney cells as most

people believe.

Okay. Uh, dark-kinned individuals

required about five to 10 times longer

exposure to sunlight to produce vitamin

D compared to fairkinned individuals.

So, dark skinned individuals living in

high latitudes are likely to develop

severe vitamin D deficiency and they are

more susceptible to a wide range of

apparently unrelated diseases like

tuberculosis and hypertension.

the at least in Brazil at least in Brazil

Brazil

the the sunscreen uh was launched in

1960 in 1984.

So from that moment on there were a lot

of uh

of propaganda trying to uh make people

to avoid any kind of any minimal

exposure to

sunlight. And this this had two

consequences. For instance, uh uh if you

use a protection factor of uh eight,

that blocks approximately 95 uh

production 95% of production of vitamin

D. And if you use a factor of 15 then

you approximately

99% of the continuous production of

vitamin D will be blocked.

So in addition to that the second

consequence is that sunscreens can

contain aluminum hydroxide coated

titanium dioxide nanop particles and

those nanop particles can penetrate the intact

intact

skin and aluminum is um extremely toxic

metal. Uh that vitamin D is not actually

a vitamin. It's a steroid hormone. It

converts into a hormone in several of

human cells and it's needed by nearly

all cells for their functions. Low

vitamin D levels play a role in the

development of many

diseases. So this is the number of uh

just a few examples uh of diseases that

are affected by the level of vitamin D

that a person has. And you see uh for

general human health you have almost uh

two million papers already

published. U this led us to this u

publications by stamp in 2012. He said

that vitamin D is as fundamental as the

sun and the closest we have to a panacea.

uh rel uh regarding the immune system,

we have more than half a million

publications uh uh available in Google

Scholar. And here is here is just

a a slide to demonstrate how important

vitamin D is for the immune cells.

Suppose that you have immune cells that has

has

fagocited miccoacterium

tuberculosis. So it's within the cell uh

and the cell has to destroy it. Uh in

order to do that, mcoacterian

tuberculosis as any other uh bacteria

stimulated the stall-like

receptors and as a consequences as a

consequence of of that uh messages uh

are sent chemical messages are sent to

the nuclei of of imunos

cells and this makes immun cells to

express the one alpha

hydroxilase which turns uh uh the 25

hydroxyd 125 hydroxyd which is the

active form of vitamin D and this active

form of vitamin D stimulates the vitamin

D receptor as a consequence of that uh

catal catalyines are produced and these

are compounds that

destroyed virtually any kind of

microorganism that has invi in invaded

our our body. So we see uh how important

vitamin D is for the immune

system. If we don't have vitamin D then

the bacteria like a mcoacterium

tuberculosis will remain alive in in the

within the immune cells.

cells.

Um so

uh if we look for vitamin D and

infectious disease, this slide so shows

uh by uh two

2021 there were

um 200 almost 300,000 peer-reviewed

publications on the functions of vitamin

D in the immune system. And today in

2025 we have almost 400 papers

published. Um regarding infectious

disease you see this uh large number of

publications showing how vitamin D level

is important to control all of those infectious

infectious

diseases. I would like to show you an

example of that by presenting Dr.

August. Um he died in

1954. Uh he was a Swiss physician who

treated tuberculosis in the first half

of the

'90s at a time when no effective

antibiotic were available to combat to

combat that highly contagious chronic

disease. And uh he built up he built up

in the Swiss

Alps at 2,000 m above the sea level. He

built up uh uh 36 cifications with large

balconies as we you see

here. And uh he used to treat

tuberculosis by

exposing the his patients to sunlight.

And the reason why he had to to be uh

200 mters 2,000 meters above the sea

level is because he wanted to be above

uh the clouds so that he would have uh

sunlight throughout the

year. So the treatment consistent

considered consisted of daily

exalinating solar exposure.

uh his buildings were called

sanatoriums. Uh one senator one

sanatorium situated in Davos appears in

the novel the magic m mountains by

Thomas man who was first published in

1924. This is

uh an example of of his uh results. On

the left side of the slide, we observe a

four year old patient with 34 fossai of oste

oste osteitis

osteitis

adenitis like we see here. Um numerous

ulcers as this one. I would like you to

pay attention to this one and tuberculus

affecting his right arm, right forearm.

The patient also presented presents with

advanced tuberculosis affecting both

feet, the right hand, the left lung and

uh the abdomen. We call it the knives.

He was ex um extremely thin, had a lot

of he had lost a lot of body weight and

at a level that we call texia.

um his uh lower uh left shoulder

suggests that he had uh also

had ricketetts. And uh it's important to

say that

ricketetts children with ricketetts

frequently died because of

tuberculosis. And at some point some

medical doctors [Music]

[Music]

uh uh thought that tuberculosis and

ricketetts were had the same

origin. On the left on the right side of

the slide we see the same patient one

year later healing of users

deconstruction of bones muscles and the

general condition. And you see that uh

that user is now uh

healed at a time at a time when the

importance of vitamin D for immune

system was not known. Dr. Holier

credited his the success of his

treatment to exposure to sunlight and to

the pure pure air of the mountains.

The effectiveness of solar exposure in

treating tuberculosis is evidenced by

the establishment of sanatoriums in

various locations worldwide including

the mountains regions of sound and

Brazil. Um however at some point the

senators were fitted with the glass

windows and glass blocks the UVB rays

which are required for vitamin vitamin D

synthesis in the skin. As a result, the

sanitarium seized treating tuberculosis

and were closed uh at a time when the

first antib antibiotic for tuberculosis

treatment. The injected injectable

streptoycin was introduced to the

market. Now

senators uh turned into hotels in the

Swiss mountains.

So low low vitamin D leads to low gel

sighting synthesis allowing allowing

microbes to remain alive within the immune

immune

cells and that leads us to the tro

Trojan horse mechanism. We see here the

structure of the blood brain barrier uh

including the

astroitic participating in this barrier.

And we see that some virus like HIV

virus when you have low levels of

vitamin D they are not destroyed by uh

the immune cells and the when the immune

cells penetrate the the bloodb brain

barrier because they they have the

mechanism those cells have the

mechanisms required for this penetration

uh it's carrying virus so that that's uh

the Okay. Uh when infected

uh the brain becomes infected by HIV and

several other fact other virus probably

like some in some kind of some types of

um severe missiles

and and like in in polio you also have

the same mechanism. This is called the

Trojan horse mechanism because uh the

virus enters the brain within the uh the

immune cells and by doing that they by

barrier. Uh in September 2018, the WH

WH called for urgent action to end the tuberculosis

tuberculosis

epidemic. Prior to the COVID epidemic,

tuberculosis was the dead deadliest

infectious diseases. It was killing like

2,000 people per year worldwide per day.

Worldwide, I'm sorry, per day. The

combined use of multiple antibiotics to

combine the antibiotic resistance has

shown limited effectiveness

nowadays. So autoimmunity is this is an

important issue to our protocol.

Autoimmune diseases are almost always

triggered by stressful life events and

managing emotional stress should be

regarded as essential for the success of

all the therapeutic approaches.

not only to related to autoimmune

diseases but also uh to uh several other

diseases. So then we are merged into

this uh vicial cycle cycle when

emotional distress leads to reduced

magnesium and as magnesium is required

for vitamin D activation then you have

reduced vitamin D activity and that's uh

increases the

possibility of acquiring an autoimmunity

disorder and when the patient is has

acquired autoimmune disorder then this

contributes to uh to deepen the emotional

emotional

distress. So reduced magnism also uh u

in causes

um excessive reaction to the to daily

life problems and uh increases emotional distress.

distress.

So this emotional distress uh

um this disrupts the epigenetic control

of dirt genes that called the snips that

we all have. We all have dirty jeans but

they are usually switched off since uh

since prenatal life and we have when we

have high level of stress is this in a

way uh switched on those

genes. So if you f look for autoimmune

disorders and stress stressful life

events we know we today have like more

almost 12,000 papers

published. Uh this is an

example association between stressful

disorders. U now going to vitamin D and

autoimmune diseases. the issue of

vitamin D and autoimmune disease

diseases. We have more than 200,000 papers

papers

published. And so all those autoimmune

diseases have tens of thousands of

papers published relating them to uh low

levels of vitamin

D. So

um how vitamin D works in in autoimmune disorders?

disorders?

uh an autoimmune disease is mediated by

abnormal immunal response which is called

called

TH17. There are

uh almost

300,000 papers showing that this is the

mechanism involved in the origin of autoimmune

autoimmune

diseases. And vitamin D inhibits

BH17. We have uh more than

3,000 papers 3,000 papers showing uh the

property of vitamin D uh related to

inhibition of uh of

TH17. You see it suppresses the DH7

cytoine production. This

This

is one example of this these

publications. So this

uh now I this slide is to review the

meth metabolism of vitamin D within

immunity cells. Vitamin D choleiciferol

is hydroxilated in the liver and

released in the circulation. So vitamin

D 25

hydroxid enters the cell under goes a

second hydroxilation within immune cells

and uh the resulting 125 hydroxyd

uh stimulates VDR vitamin D uh receptor

that inhibits uh EH17 programs and

stimulates the proliferation of

Okay, this is the same slide. Um, so

vitamin D and TH17 as I told you u we

have like more than three 30,000 publications

publications

um and how we adjust the dose of vitamin

D. Here we have the parathyroid cells.

cell of the thyroid, one of the four par

thyroid glands that we have uh close to

our thyroid cell, thyroid gland and the

vitamin D that is activated in the liver

also enters the thyroid thyroid cells

uh is

activated and stimulate VDR and the

simulate the simulation of

VDR by the active form of vitamin D

inhibits the production of PDH parathyroid

parathyroid

hormone. So what we do in order to uh to

match the level of resistance status a

person has to vitamin D is to measure uh

PTH before the treatment and after five

months of treatment. So when we increase

PTH when we increase vitamin D, PTH

decreases and the goal is to decrease

PTH to just above the lower level of the

reference rate range for

PTH. So PTH inhibition has two

advantages to as cons as as uh as

concerned to to our protocol using high

doses of vitamin D. It shows the level

of of individual resistance to vitamin D

and if we if vitamin if PTH is not

decreased below the lower level of the

reference range then this assures

safety. It means that uh we are uh

pretty sure that there will be no uh no

intoxication. Intoxication meaning

increased level of

calcium. So this is before we go on um

are you going to talk a little bit more

about what vitamin D resistance is

because we didn't quite go into that

part. I know you've talked about it

before in some of your presentations, so

maybe you already have it in your slides.

slides.

Okay. Uh I I can give you an example. Um

patients who who have

uh who have autoimmune

disorders they have uh automorphic

changes affecting any combination of the

nine genes that is required for vitamin D

effects. So uh we don't know the level

of resistance that a specific patient

may have. So you we have to test

it. So we give a testing dose that could

be something like 1,000 units of vitamin

D per kilogram per day. And so vitamin D

starts increasing and it takes like

three, four or five months to level

off. So we measure PTH before uh

starting vitamin D. uh the sub this

supplement with high doses of vitamin D

and after five

months. So at the end of this five

months uh we we see how much vitamin D

when we increased vitamin D how much PTH

decreased. That was what what I was

trying to show you when I when I showed

this. Suppose that this is the level of

uh of this is the level of u of PTH that

you you have before the treatment

uh before taking 1,000 units of vitamin

D per kilogram per day. And this is the

level of PTH that you have five months later.

later.

So it should be just above the lower

level of the reference range. If it has

below that level, so I have to decrease

the dose the daily dose of vitamin D.

It's a it's if it is uh far above the

lower level of the reverence range. So I

still have to give more vitamin D uh as

compared to what I was giving uh uh

during this period of uh uh test. Okay.

So uh it's this the first six months is

like a testing period. We give a testing

dose and we see how much uh the level of

vitamin how much the level of PDH will

decrease. So at the end of this five

months periods when we receive the

patients in a second appointment then I

look at the level of PTH and I have to

calculate how much PTH how much vitamin

D uh how much vitamin D I I have to give

in additional to that uh previous dose

or how much vitamin D I have to decrease

in as compared to that previous dose. I

don't I don't know if I explain myself

properly. So, uh what we see here in

this slide is uh an enzyme that is called

called

CYP27B1 which is a kind of code for the

enzyme that activates vitamin D. Uh

turning 25 hydroxyd into 125

hydroxid which is the active form of

vitamin D.

uh the gene so that that is used to

express this

enzyme maybe change it may be uh

polymorphic in patients with autoimmune

disorders like multiple scerosis like uh

this publication is

showing. So in order to understand how [Music]

[Music]

the resistance of vitamin D appears in

this case we have to look at the

u and at the curve showing how the

enzyme velocity changes according to

substrate concentration.

So as I increase the substrate

concentration of a normal enzyme

uh the velocity increases but at some

point it will reach the maximum

velocity. So in order to characterize

the activity of this enzyme, you have to

uh calculate the half of this maximal uh

velocity and the concentration of

substrate that you have to achieve in

order to reach this level of uh

velocity. And this concentration is

called uh mikis mending constant or cm

km. If you have a enzyme that is whose

gene is an enzyme that is expressed from

a gene that is

polymorphic then the curve will be

different. Uh you will not reach the

same level of maximal velocity.

uh and in order to reach the same uh km

you will have to the same velocity the

same uh enzyme reaction velocity you

will have to achieve a higher

concentration of substrate so that you

have the same uh you have to achieve a

higher concentration of of substrate to

achieve the same velocity that you would

achieve in the normal enzyme with a

lower level of substrate

concentration. that that's explains why

we have to increase the level of

substrate uh in patients with uh uh with

autoimmune disorder increase the

substrate to that enzyme which is 25 the

substrate is 25

hydroxyd and if you have a enzyme that is

uh has a polymorphic

change gene that is causes

uh even

um higher effect on enzyme activity. You

will have to reach a much higher uh

substrate concentration to achieve the

same uh enzyme reaction velocity.

This explains why uh we have to use high

doses of vitamin D uh to

achieve concentration of 25 hydroxy that

is uh much larger than usual in order to

keep the same uh the same uh uh reaction velocity.

velocity.

uh I think this explains uh this is a

good example to explain why we have to

give high doses of vitamin D to patients

with autoimmune disorders who have

polymorphic genes. Uh the same type of u of

uh enzyme behavior is found when you uh

study the the interaction between

u between the active form of vitamin D

and the vitamin D receptor. vitamin D

receptor or receptors of of several

receptors would behave like an enzyme

and will uh will have the same

profile so that when we have a decreased

affinity of the receptor for its uh

agonist which is the active form of

vitamin D uh when the the structure of

this vitamin D receptor is changed. You

need a higher concentration of uh uh

substrate which is the active form of

vitamin D in order to achieve the same biological

effect. What do you think? That sounds

great. Um so just to clarify because we

talked about snips as well. So a

polymorphism is the same as a snip, right?

right?

Yes, SNIP is a single nucleotide polymorphism.

polymorphism.

And so individuals who have one or more

snips, say they have one snip, they

might be that blue line in the middle,

but if they have two, they might be that

that red line down below. So that's

another way to describe vitamin D

resistance because these people with the

polymorphisms are what we're what we're

terming as vitamin D resistant

individuals. Correct. Correct. And

important to say

that we vitamin D requires like nine

genes to uh to to function but to

um for his biological function. Okay.

Vitamin D requires nine genes for his

biological function. And you may have

any combination of those of

polymorphisms affecting

uh those genes you can have one, two,

three or all of them combined and each

polymorphic change can be different

uh affecting one single gene. I mean

that when you compare two people with

uh the

same with the same

um with the same with the same autoimmune

autoimmune

disease. Uh those pe those two people

can have different combinations of nine

different polymorphic changes.

uh and so it's impossible to calculate

uh the level of resistance just by

knowing the combination of uh

polymorphic genes that this this this

person has.

uh and that that's why we use the final

effect which is how much PTH has decreased

decreased

uh when you give a testing dose of

vitamin D for 5 months and then you you

see how much uh how much the v the PDH

has decreased and then then you can

calculate how much vitamin D you you can

add to the initial dose or how much

vitamin D you can take away from the

initial dose in order to match the level

of resistance. So this is uh one of of

my first patients that I treated with.

She had uh

SLE and that was the result of only

10,000 units of vetine D per day after

six months of treatment. So, uh you

imagine how impressed I was because uh

that was the only changes. The only

change that I did in her treatment was

to add vitamin D 10,000 units per

day. So, you see her right face here,

the difference between before and after

the treatment. Uh the left face.

face.

Uh so here you see another patient with

psoriasis. Uh you see the psori

psoriasis lesions uh affecting this area

of her face. And after 6 months taking

10,000 units of vitamin D, you see this

benefit that she had. You see her the

difference giving her 10,000 units of

vitamin D within after 6 months. to see

uh how improved the lesions

were. So this is the same

patient. So here you have patients with multiple

multiple

sclerosis. Um

uh she was born in 1988

82. Uh and this is this is when she had

the first flare of multiple scerosis. So

this was this MRI was taken in March

14 and you see those lesions though

those were recent legions because it was

her first flare. Okay, it it's important

important to say that because uh vitamin

D has also effects on the cells that

produce myeline

uh which is called olingodendo sites. So

it uh promotes remalination in multiple

scerosis but that remalination only

occurs uh in when you have recent

lesions when you have all lesions that

are older than one year when back when

you start the treatment. So it's more

difficult to have remalination of

visions. But that was uh that provides a

comparison between between uh March 2011

and July

2012. The two

uh the two um more more than one year

had elapsed at the between one MRI and another.

another.

uh this lesions or those lesions were

active in the first uh M set of MRIs.

I'm not showing showing you this here

So you see here another patient who had

a a lesion MS leision affecting a

critical area of the

brain can cause this leision can cause

severe symptoms and

disability. Uh it was a patient born in 89

1989. The first slide was taken uh the

first slide is on MRI made in April 18,

2011 and the second slide was uh uh

done two about two years later more than

two years later and you see the

disappearance of that

lesion. It was also a recent lesion.

There were kind of lesions old lesions

here who had le not so old lesions but

you see that maybe the spinal cord is a

little bit swollen because of some

lesions were present here but they also

had disappeared two and a half lit years

later. So this is a severe type of

multiple sclerosis. It's called balo

concentric sclerosis.

It's a severe disease related to multiple

multiple

sclerosis. Usually patients do not

survive for more than two or three years

after the the diagnosis.

And you see uh the first MRI that was

taken in October

2008 and uh there were several MRIs in

between but uh uh like five years later

you only have the scar of those lesions

and no additional lesion. So that was

impressive to me. I was impressed with

that case because as a neurologist I know

know

how balance concentric is sclerosis is severe

severe

disease. So this slide is uh to show why

we should not use the active form of

vitamin D uh to treat those

patients. Um so choleiciferol which is

the form of vitamin D that we give to

patients orally uh goes to the liver uh

under goes the first hydrox

hydroxilation turning it turning it into

25 hydroxyd

uh it had this uh increase in 25

hydroxyd has no effect does not inhibit

uh the 25 hydroxy hydroxilase is located

in the

liver. So uh the 25 hydroxyd goes to

kidney and to immune cells like

macrofasages and you will find uh one

alpha hydroxilase in both sides in both cells.

cells.

Um so they turned one alpha hydroxyan

uh into they turn in the 25 hydroxy into

the active form of vitamin D. The kidney

releases into the circulation the blood

serum. But the immune cells like

macrofasages use this active form of

vitamin D for

uh to supply its needs

uh not for not it's not supposed to

release in the

circulation. So uh when the 120 one

alpha 125 hydroxyd is released in the

circulation it inhibits the one alpha

hydroxilase is located in the kidneys

and this is an important step to prevent

uh to prevent uh intoxication uh

because 125 hydroxyd uh is capable of

increasing inreasing calcium levels uh

to a very high level. So we should avoid

having that. And when we give a

colliciferol you see that the when the

the kidneys release 125 hydroxyd

uh the 125 hydroxyd released in the

circulation inhibits the uh renal

enzyme. So uh 125 hydroxyd go to uh to

the intestines and bones uh and

uh it releases calcium in the

circulation and the the release of

calcium in the circulation further

inhibits the one alpha hydroxilase uh

located in the

kidneys. But this has no calcium level

has no effect in the one alpha

hydroxilase located in the immune cells.

So that's the reason why we should use

molecol and not never use 125

hydroxyd because if you use 125 hydroxid

you will bypass all this uh this

controlling homeostatic

mechanisms that and this does not happen

colliciferol. So this is something

important. U it shows uh how uh one

alpha hydroxy works both in the kidneys

and in immune cells and in several other

tissues like the brain, placenta uh and

several other tissues. So uh the

registed form of one of hydroxilines is

capable of synthesizing 125 hydroxydine

but it requires magnesium as a co-actor

but when it it turns 25 hydroxyd into

125 hydroxydine it gets

oxidized. So in the oxidized form one

one alpha hydrox hydroxilase cannot pick

up another molecule of 25 hydroxyd to

turn it into the active form of vitamin

D. So it has to go back to the rejected

form. uh it belongs to this enzyme

belongs to the cytochrome

P450 supper family comprising like more

than 100 enzymes. And this family of

enzymes have an auxiliary enzyme that is

called reductase of the cytochrome P4

450. And this uh uh this enzyme requires

both the active forms uh of vitamin B2

as a prostatic group

uh and it's capable of reducing the

oxidized one alpha

hydroxidase. When it when this occurs the

the

reductase is oxidized but it is quite

capable of reducing itself back to the

reducing form of cytochrome P450

P450

reductase. So uh this uh cycle has to go

on to in order to this cycle to go on

you have you need this cycle to go on.

So you in order to keep hydroxilating

vitamin D to the active form, you need

B2. Um and it's important to know that

uh like 10 to 15% of the world population

population

u has uh um registed ability to absorb uh

riboflavin. Uh several of those people

have autoimmun

disorders. This uh was demonstrated by

this uh article published in 1994. [Music]

[Music]

uh also this is extremely important

right because it's like 10,000 10% of

the whole

population it's important to say that

high doses of qualif should be taken

under the supervision of an exper

experienced physician to avoid army and

renal function

real quickly Dr. Dr. Coinbra, can you

just define what high dose is? Because

some people consider high dose the

10,000 IU a day. Is that the dose that

you're talking about? Or are you talking

about the doses that you use in your

protocol the 1,000 IU per kilogram?

Correct. Yes. Okay. 10,000 units per day

is is

um is an amount of vitamin D that you

can produce by solar exposure.

So nobody has ever been be nobody has

ever got intoxicated

uh with vitamin D by exposing uh the

skin to sunlight.

So if you are lying down on horizontal

position, you have a fair skin and uh

the sun uh is high enough

uh you have your skin is a young skin

uh then you can produce this amount of

vitamin D within like 20

minutes or 30 minutes. So, it's hard to

believe that people still believe that

10,000 units of vitamin D is a high dose

of vitamin D considering that this is

easily produced by uh exposing the skin

to sunlight. So when I'm talking about

high levels of high doses of vitamin D,

I'm talking the do about the doses that

we give to patient the patients

initially which is uh uh 1,000 units of

vitamin D per kilogram per day. So this

is a high dose and and maybe it could be

called a therapeutic dose because it's

what you're using to help treat these

patients and not necessarily what uh

somebody in the general population might

take just to maintain their vitamin D

levels. Never the general population

should not take this high dose of

vitamin D. Uh only uh patients who have

autoimmune disorders uh and under

medical supervision. Mhm. But I'm I'm

glad we clarified that because the the

therapeutic use is the use that should be

um used with a medical provider who is

observing and watching for toxicity and

measuring the PTH and all of that. I

just wanted to make that clear. So I'm

going to let you go ahead and keep keep

moving forward. Okay.

Okay. um

u when we give high doses of vitamin D,

I was talking about the initial dose of

uh one uh 1,000 units of vitamin D per

kilogram per day. This was is usually

our testing dose for diseases like

say rheumatoid

arthritis to see how much the PDH will

decrease when we increase the dose of

vitamin D. But uh if I am treating a

disease like psoriasis, I don't have to start

start

giving that amount of vitamin D. I can

give it

I can give like um say for a patient who

who weights like 50 kilograms I can give

like 30,000 or 40,000 units per day as a

testing dose because it's not an

emergency okay but that that that

changes when I have an emergency for

instance if I have a patient with

multiple scerosis who is at risk of

losing his vision

because of optic

neurites or just had an an episode of

optical neurites like um two weeks

ago uh and is coming for the first

appointment. So this is to me this is an

emergency because I know that if I give

I give high doses and I immediately

increase the dose of vitamin D uh the

level of vitamin D to a a high level I

know that I can reverse the um the

visual loss that this patient has. So in

this case I would uh give to this

patient a loading dose of vitamin

D and what I'm going to tell you is has

been published uh if I don't probably it

was published by a group of Italian

researchers in 2018 they

showed if you give uh

600,000 units of vitamin D as a single dose

orally. On day three, the patient will

have a a level of vitamin D which is

around 18 nos per

ml. Uh and that it means that I will

normalize the level of vitamin D

immediately by giving this by giving

this loading dose. So but I will not

give this loading dose to a patient that

comes for the first appointment and has

only uh only

psoriasis. Uh there is no uh there's no

emergency in that situation. I can uh

check the level of resistance to that

patient 6 months later and adjust the

dose. There's no rush in increasing the

dose of vitamin D immediately. But in a

patient in that situation who had a

flare of multiple scerosis affecting his

optical nerve then I may give him uh uh

this loading dose. I will definitely

gave give him this loading dose because

I want I I don't want to miss the uh

therapeutical window to reverse uh his

visual disabilities.

uh I need uh high level of vitamin D to

be achieved immediately uh so that uh I

can get the res effects of vitamin D in

terms of remalination of the optic

nerve. Is that clear enough? So the

initial dose may vary according to the

patient's condition and to his to the

type of disease that he is having.

Okay. Uh okay. So um but we can have

intoxication of vitamin D because uh

using high doses of vitamin D because

patients should follow a strict diet.

They should not have uh dairy products

in their diet and order uh order uh diet

eat items that are high that has high

level have high level of of

calcium. So they have to follow this

restricted uh calcium diet.

uh and sometimes they just they are

doing so well that they just don't feel

that this is is important and they uh

they don't they don't uh follow the diet

as strictly as they were recommended

to. Uh so one of the causes of uh of

intoxication is a unreliable source of

vitamin D. Another uh another uh cause

of intoxication is urinary tract

infections particularly pile nephritis nephritis.

nephritis.

uh for some reason when you have a a

urinary tract infection even if you are

not taking vitamin D any supplement of

vitamin D your calcium level may

increase for some for in there a

mechanism by which urinary tract

infection decreases the uh

urinary elimination of

calcium. Uh so it's an important uh part

of the protocol is to uh prevent urinary tract

tract

infections and because uh the uh urinary

tract infections are caused by by

microorganism that uh are present in our

faces. It's extremely important and

extremely effective uh to wash the p per

panal area uh after having a bowel

movement so that you remove the the all

microorganisms from that area. Sometimes

we we may for some patients who who have

a recurrent urinary tract infections

after washing that area they have to

apply a topic uh antibiotic

uh after washing that area. So poor

compliance to with dietary uh calcium

restriction is another possible cause of intoxication.

intoxication.

hyperthyroidism, uncontrolled hyper

hyperyroidism like embezzle graves

disease or um or

nodules uh in the thyroid gland that

produce high uh levels high amounts of

thyroid hormones. uh this condition can

when when it's associated with high

doses of vitamin D can lead to uh

intoxication and this is because thyroid hormones

hormones

um just like vitamin D they may remove

calcium from our bones and the patient

get intoxicated not because of the

calcium in their diets but because of

that of large amounts of calcium that are released in their bones.

are released in their bones. in that condition. So if we have a

in that condition. So if we have a patient with Graves disease, we first we

patient with Graves disease, we first we have to control the Graves disease by

have to control the Graves disease by using proper medications that decrease

using proper medications that decrease the release of thyroid hormones from the

the release of thyroid hormones from the thyroid

thyroid gland. Um so it's extremely important to

gland. Um so it's extremely important to have uh hyperyroidism under control

have uh hyperyroidism under control before starting this treatment.

before starting this treatment. uh basog graves

uh basog graves is autoimmune disorder and responds to

is autoimmune disorder and responds to high dose of vitamin D but we cannot

high dose of vitamin D but we cannot start vitamin D high doses of vitamin D

start vitamin D high doses of vitamin D without controlling uh the release of

without controlling uh the release of large amounts of thyroid hormones from

large amounts of thyroid hormones from the thyroid gland. So uh uh we found

the thyroid gland. So uh uh we found this is for experiences that when

this is for experiences that when patients taking are taking very high

patients taking are taking very high doses of vitamin C they may get

doses of vitamin C they may get intoxicated. Uh and high doses of

intoxicated. Uh and high doses of vitamin D very high doses of vitamin C

vitamin D very high doses of vitamin C uh produce a kind of a situation called

uh produce a kind of a situation called systemic

systemic oxyosis. So we advise patient uh

oxyosis. So we advise patient uh patients under this treatment to avoid

patients under this treatment to avoid supplements of vitamin C higher than uh

supplements of vitamin C higher than uh 250 mgs per

250 mgs per day. Um so we also found that lithium uh

day. Um so we also found that lithium uh this this drug that is used in

this this drug that is used in psychiatry lith lithium uh is can induce

psychiatry lith lithium uh is can induce hyper

hyper parathyroidism. So it it can increase

parathyroidism. So it it can increase the release of pth in parathyroid

the release of pth in parathyroid hormones and this can cause

hormones and this can cause intoxication. So if you are at the same

intoxication. So if you are at the same time using uh a high dose of vitamin D

time using uh a high dose of vitamin D and you have a high level of PTH because

and you have a high level of PTH because uh because uh you have

uh because uh you have uh uh you are taking lithium and lithium

uh uh you are taking lithium and lithium increases uh increases the release of

increases uh increases the release of PTH by parathyroid hormones. So li the

PTH by parathyroid hormones. So li the use of lithium can cause intoxication in

use of lithium can cause intoxication in when we are using this protocol. Um real

when we are using this protocol. Um real quick about vitamin C. Um is it only

quick about vitamin C. Um is it only vitamin C from supplements or do you

vitamin C from supplements or do you also have to worry about vitamin C from

also have to worry about vitamin C from foods?

foods? Only from supplements. Okay. um patients

Only from supplements. Okay. um patients can take as much vitamin C as they want

can take as much vitamin C as they want by taking um fruits and and and other uh

by taking um fruits and and and other uh foods like that. So we also found uh

foods like that. So we also found uh that aromati aromatase inhibitors can

that aromati aromatase inhibitors can cause can increase calcium levels but at

cause can increase calcium levels but at this point I don't know the mechanism

this point I don't know the mechanism related to that but we found that that

related to that but we found that that on some patients started using those

on some patients started using those aromatase inhibitors for uh prevention

aromatase inhibitors for uh prevention of breast cancer they they they some of

of breast cancer they they they some of those patients got uh intoxicated

those patients got uh intoxicated with vitamin D. I mean that the dark

with vitamin D. I mean that the dark culture levels increased above the

culture levels increased above the normal

range. So we have a I don't know if you would like to go through those steps but

would like to go through those steps but we have a protocol when when

we have a protocol when when intoxication happens we have a protocol

intoxication happens we have a protocol to to

to to to use to in order to uh to induce

to use to in order to uh to induce recovery from

recovery from intoxication. Um maybe it's

intoxication. Um maybe it's not interesting to go into that uh those

not interesting to go into that uh those steps. Let's go through it because we

steps. Let's go through it because we might have some practitioners who are

might have some practitioners who are interested in learning more and maybe

interested in learning more and maybe even reaching out to you for

even reaching out to you for um training. Uh patients who are under

um training. Uh patients who are under this treatment uh should be aware of

this treatment uh should be aware of symptoms of uh increased calcium levels

symptoms of uh increased calcium levels such as persistent nausea and

such as persistent nausea and constipation.

constipation. When that happens, they should stop

When that happens, they should stop picking not not only nausea, isolated

picking not not only nausea, isolated nausea or isolated

nausea or isolated constipation. But when the two symptoms

constipation. But when the two symptoms are associated, then they should be

are associated, then they should be concerned about the possibility of

concerned about the possibility of having uh high levels of calcium uh

having uh high levels of calcium uh circulating calcium.

circulating calcium. So the first the first measure is to

So the first the first measure is to stop taking vitamin D uh and all other

stop taking vitamin D uh and all other supplements that we uh we give to those

supplements that we uh we give to those patients except for magnesium. This is

patients except for magnesium. This is important because magnesium is uh is a

important because magnesium is uh is a calcium natural calcium blocker and it's

calcium natural calcium blocker and it's important to keep the the

important to keep the the the the intake of magnesium supplements

the the intake of magnesium supplements and sometimes even to increase that that

and sometimes even to increase that that dose.

dose. uh so they have to increase the daily

uh so they have to increase the daily hydration uh for one more liter because

hydration uh for one more liter because usually when the patients start on on

usually when the patients start on on that treatment we ask them to take at

that treatment we ask them to take at least 2.5 liters of liquids in general

least 2.5 liters of liquids in general per day. But uh in that situation when

per day. But uh in that situation when those two symptoms are associated then

those two symptoms are associated then we ask them to uh to increase the the

we ask them to uh to increase the the daily hydration to at least 3.5 liters

daily hydration to at least 3.5 liters per

per day. So we double the the daily amount

day. So we double the the daily amount of uh magnesium that is we use in this

of uh magnesium that is we use in this protocol. We usually usually use 100

protocol. We usually usually use 100 milligrams of elemental magna magnesium

milligrams of elemental magna magnesium uh three or four times per day and uh we

uh three or four times per day and uh we have to double that

amount. As another step we start using ferosomide which

ferosomide which is dur dialectric or diuretical drug 40

is dur dialectric or diuretical drug 40 migrams one tablet twice a day for one

migrams one tablet twice a day for one week and then reduced to once a week. We

week and then reduced to once a week. We start supplementation of potassium to

start supplementation of potassium to avoid uh the side effect of verosamide

avoid uh the side effect of verosamide 100 milligrams one tablet twice a day

100 milligrams one tablet twice a day for one week and then reduced to once a

for one week and then reduced to once a week. We also give them alendonate by

week. We also give them alendonate by bifosphonate because bifphosonate

bifosphonate because bifphosonate immediately blocks the

immediately blocks the the blocks the release of

the blocks the release of calcium from the the patient's bones.

calcium from the the patient's bones. And it's important to say

And it's important to say that patients usually get in intoxicated

that patients usually get in intoxicated because of of the because of the calcium

because of of the because of the calcium the amount of the large amount of

the amount of the large amount of calcium that they are releasing uh from

calcium that they are releasing uh from their bone tissue and not because of the

their bone tissue and not because of the diet. Usually it's not because of the

diet. Usually it's not because of the diet because they are usually following

diet because they are usually following the diet.

the diet. uh so uh giving a boss is way to stop

uh so uh giving a boss is way to stop the intoxication immediately because you

the intoxication immediately because you stop the releasing of calcium from the

stop the releasing of calcium from the bones. So we ask you we ask patients to

bones. So we ask you we ask patients to collect blood and urine samples once a

collect blood and urine samples once a week as prescribed and they are sending

week as prescribed and they are sending those results to us as soon as the the

those results to us as soon as the the doses the results are available. This is

doses the results are available. This is different

different uh as compared to what happens in US

uh as compared to what happens in US because uh who receives the the the

because uh who receives the the the laboratory results in US seems to be the

laboratory results in US seems to be the doctor. In Brazil patients and doctor

doctor. In Brazil patients and doctor and doctors have access to laboratory

and doctors have access to laboratory results.

results. Um that's um in summary that's what we

Um that's um in summary that's what we do when we have a case of intoxication

do when we have a case of intoxication and all doctors that are have been

and all doctors that are have been trained in our clinic uh uh are taught

trained in our clinic uh uh are taught uh to use this protocol

uh to use this protocol uh as part of that training.

So those are the lab tests that we use whenever we have a case of

whenever we have a case of intoxication. Uh we we are we order

intoxication. Uh we we are we order paratone.

paratone. Obviously if the parrom is above above

Obviously if the parrom is above above the lower limit of the normal range the

the lower limit of the normal range the patient is not intoxicated because when

patient is not intoxicated because when calcium increases above the uh the its

calcium increases above the uh the its upper level

upper level upper level

upper level of normal range when calcium is

of normal range when calcium is increasing is increased it inhibits par

increasing is increased it inhibits par it inhibits the release of parathon by

it inhibits the release of parathon by parathyroid glands.

So total and ionized calcium are one of the mo those four

um items are um blood tests and urinary tests that we always order in order to

tests that we always order in order to treat uh to treat intoxications. uh TSH

treat uh to treat intoxications. uh TSH is also included here because uh of

is also included here because uh of course we want to know if the cause of

course we want to know if the cause of intoxication is hyperarothyroidism that

intoxication is hyperarothyroidism that may begin at some

may begin at some point. Um so we also order urinary

point. Um so we also order urinary uh culture culture of urine to to assess

uh culture culture of urine to to assess sensitivity of antibiotics and we start

sensitivity of antibiotics and we start antibiotic as soon as we

antibiotic as soon as we receive positive

receive positive urine test urine

urine test urine culture.

culture. Um so this is related to your question.

Um so this is related to your question. And can you answer the question for me?

And can you answer the question for me? Is is vitamin D toxicity once the

Is is vitamin D toxicity once the patient has shown symptoms? Is are all

patient has shown symptoms? Is are all of those effects completely reversible

of those effects completely reversible or are there any permanent is there any

or are there any permanent is there any permanent damage from the vitamin D

permanent damage from the vitamin D toxicity that these patients experience?

toxicity that these patients experience? uh if we start the treatment of the uh

uh if we start the treatment of the uh to reduce intox to stop intoxication

to reduce intox to stop intoxication immediately

immediately uh then everything is reversed. All

uh then everything is reversed. All damage to kidneys is maybe reversed. If

damage to kidneys is maybe reversed. If we take a long time to start those that

we take a long time to start those that detoxification protocol then it

detoxification protocol then it might the patient may have some uh

might the patient may have some uh damage to his renal function. But that's

damage to his renal function. But that's why we are deeply concerned about uh

why we are deeply concerned about uh having the patients are aware that they

having the patients are aware that they should let us know as soon as uh they

should let us know as soon as uh they are having those symptoms and we gave

are having those symptoms and we gave them laboratory prescriptions. I mean

them laboratory prescriptions. I mean laboratory orders to so that they have

laboratory orders to so that they have laboratory orders to immediately collect

laboratory orders to immediately collect the blood samples as soon as those

the blood samples as soon as those symptoms started. Got it. Okay. So this

symptoms started. Got it. Okay. So this is something that we always give it give

is something that we always give it give patients

patients um

um laboratory orders without a date so that

laboratory orders without a date so that they can use it whenever they want as

they can use it whenever they want as soon as it's necessary.

soon as it's necessary. uh even before they contact us they may

uh even before they contact us they may start measuring calcium levels in the

start measuring calcium levels in the urine because the urine the calcium the

urine because the urine the calcium the urinary calcium level is the first to

urinary calcium level is the first to increase. So if the urinary calcium is

increase. So if the urinary calcium is within the normal range uh then it's

within the normal range uh then it's unlikely that this patient has uh is

unlikely that this patient has uh is intoxicated with the vitamin D.

intoxicated with the vitamin D. And you also mentioned that the calcium

And you also mentioned that the calcium usually comes from the bones. Do you

usually comes from the bones. Do you ever see any effect on the bone health

ever see any effect on the bone health with this protocol? Yes. Uh and this is

with this protocol? Yes. Uh and this is important question.

um when we uh increase when we give a dose of vitamin D like 10,000 units of

dose of vitamin D like 10,000 units of vitamin D, you may expect to have

vitamin D, you may expect to have increase the absorption of calcium to

increase the absorption of calcium to your bones.

your bones. uh when you increase the dose of vitamin

uh when you increase the dose of vitamin D to more than 20,000 units per day uh

D to more than 20,000 units per day uh then uh the effect on bones is both

then uh the effect on bones is both increasing the absorption of calcium uh

increasing the absorption of calcium uh the stimulation of

the stimulation of osteoblasts and also the increase in

osteoblasts and also the increase in uh on the release of calcin from the

uh on the release of calcin from the bones due to the simulation of osteo

bones due to the simulation of osteo class. So at some point you have both a

class. So at some point you have both a simulation of osteoclasts and a

simulation of osteoclasts and a simulation of

simulation of osteoblasts. And if you increase the

osteoblasts. And if you increase the dose of vitamin D further like more than

dose of vitamin D further like more than 40,000 units of vitamin D, you will

40,000 units of vitamin D, you will increase uh you will stimulate

increase uh you will stimulate osteoblasts more than you will stimulate

osteoblasts more than you will stimulate osteoblasts. So the release of calcium

osteoblasts. So the release of calcium will uh will be increased in those

will uh will be increased in those patients. And in order to prevent that

patients. And in order to prevent that the best measure to prevent that is to

the best measure to prevent that is to uh do physical

uh do physical exercise because if you have uh strong

exercise because if you have uh strong muscles, you have strong

muscles, you have strong bones. Uh you cannot have weak bones if

bones. Uh you cannot have weak bones if you have strong muscles. This is uh the

you have strong muscles. This is uh the way that nature works. If you uh submit

way that nature works. If you uh submit to your bones to uh to forces during

to your bones to uh to forces during physical exercise like like muscle

physical exercise like like muscle musculation

musculation uh to increase the the muscle mass, you

uh to increase the the muscle mass, you will also increase the calcium level

will also increase the calcium level calcium concentration on in your bones.

calcium concentration on in your bones. So it's extremely important. And it's

So it's extremely important. And it's part of our protocol. Patients cannot

part of our protocol. Patients cannot remain at home just taking u just taking

remain at home just taking u just taking high doses of vitamin D. They have to do

high doses of vitamin D. They have to do physical exercises. And I ask them to do

physical exercises. And I ask them to do physical exercises every day. Uh

physical exercises every day. Uh especially those exercises that are

especially those exercises that are related to muscle

related to muscle hips. They are uh simulated to do that

hips. They are uh simulated to do that every single day. maybe uh twice a day

every single day. maybe uh twice a day if possible twice a day and this is

if possible twice a day and this is extremely effective to prevent uh the

extremely effective to prevent uh the loss of calcium from the bone tissue.

loss of calcium from the bone tissue. Um is that what was you were asking?

Um is that what was you were asking? Yes. An additional information. Okay. Is

Yes. An additional information. Okay. Is some patients cannot have cannot do

some patients cannot have cannot do physical exercise because they are in a

physical exercise because they are in a in a wheelchair for several years. uh

in a wheelchair for several years. uh the

the um they are this is a they are in a

um they are this is a they are in a situation of uh

situation of uh irreversible damage to their spinal

irreversible damage to their spinal cord even years before they started this

cord even years before they started this treatment. So I cannot ask them to do

treatment. So I cannot ask them to do physical exercise. So in that case I

physical exercise. So in that case I have to use uh medications that stop the

have to use uh medications that stop the release of calcium from their bones at

release of calcium from their bones at the same time when I started giving them

the same time when I started giving them a higher level of vitamin D and it's

a higher level of vitamin D and it's something extremely extremely important

something extremely extremely important in regarding that question

in regarding that question u is this uh when we started paying

u is this uh when we started paying attention to

attention to the to the mental health of our

the to the mental health of our patients. Meaning uh when we started

patients. Meaning uh when we started asking them to control their emotions by

asking them to control their emotions by controlling the uh their thoughts

controlling the uh their thoughts because you are under stress because of

because you are under stress because of the thoughts that you are uh accepting

the thoughts that you are uh accepting in your mind uh because of the of the

in your mind uh because of the of the problems that you are facing.

problems that you are facing. But if you uh

But if you uh learn techniques on how to control your

learn techniques on how to control your thoughts as a way to control your your

thoughts as a way to control your your stress, I can see that those patients do

stress, I can see that those patients do not require those high levels of vitamin

not require those high levels of vitamin D. And I see in the laboratory tests

D. And I see in the laboratory tests that I have to decrease the level of uh

that I have to decrease the level of uh of vitamin D, the doses of vitamin D

of vitamin D, the doses of vitamin D because they are they seem to to be no

because they are they seem to to be no longer so resistant to vitamin D as they

longer so resistant to vitamin D as they were before.

were before. uh and this that's why the the control

uh and this that's why the the control of emotions has become the basic of this

of emotions has become the basic of this this therapy. I don't want to keep

this therapy. I don't want to keep patients on high doses of vitamin D

patients on high doses of vitamin D forever. I want to decrease their daily

forever. I want to decrease their daily doses of vitamin D and I can decrease

doses of vitamin D and I can decrease their daily doses of vitamin D if they

their daily doses of vitamin D if they decrease the level of stress. So this is

decrease the level of stress. So this is part of the treatment. I have several

part of the treatment. I have several patients that are no longer taking high

patients that are no longer taking high doses of vitamin D because they learned

doses of vitamin D because they learned how to control their emotions. So

how to control their emotions. So techniques like mindfulness

techniques like mindfulness uh are very important to those patients

uh are very important to those patients and we ask them to uh to look for those

and we ask them to uh to look for those for informations like that

for informations like that and I don't know if I could transmit how

and I don't know if I could transmit how important this is for this protocol.

important this is for this protocol. It's not about giving them high do only

It's not about giving them high do only about giving high doses of vitamin D to

about giving high doses of vitamin D to match the level of resistance. This can

match the level of resistance. This can be the first step. But as time goes by,

be the first step. But as time goes by, the patient is now uh aware that he is

the patient is now uh aware that he is not he's no longer having those symptoms

not he's no longer having those symptoms that he had before. And one of the most

that he had before. And one of the most important symptoms is fatigue. Fatigue

important symptoms is fatigue. Fatigue at

at rest. Fatigue at rest almost disappeared

rest. Fatigue at rest almost disappeared after one month of treatment. And this

after one month of treatment. And this is is a way of measuring uh the strength

is is a way of measuring uh the strength of uh um an inflammatory a systemic

of uh um an inflammatory a systemic inflammatory condition a systemic

inflammatory condition a systemic inflammatory conditions cause fatigue at

inflammatory conditions cause fatigue at rest. So uh if this is decreased after

rest. So uh if this is decreased after one one month of treatment I know that

one one month of treatment I know that the inflammation inflammatory process is

the inflammation inflammatory process is becoming under control and that's a a

becoming under control and that's a a question that I consistently ask to all

question that I consistently ask to all patients. What's your level of fatigue

patients. What's your level of fatigue in a scale from zero to 10? Uh because

in a scale from zero to 10? Uh because when they come back I will ask that

when they come back I will ask that question again. Another question that I

question again. Another question that I ask patient is something like this. Uh

ask patient is something like this. Uh suppose there is a scale an imaginary

suppose there is a scale an imaginary scale of uh of stress that goes from

scale of uh of stress that goes from zero to 10. Zero does not exist would be

zero to 10. Zero does not exist would be someone that uh does not get stressed

someone that uh does not get stressed for anything. So that that does not

for anything. So that that does not exist. But level five would be the

exist. But level five would be the average level of stress that a person uh

average level of stress that a person uh of

of the an average person of the whole of

the an average person of the whole of the population has and a person that is

the population has and a person that is facing common problems regular problems

facing common problems regular problems ordinary problems and level 10 is the

ordinary problems and level 10 is the maximum level of stress that a patient

maximum level of stress that a patient may have that someone may experience. So

may have that someone may experience. So I asked the patients uh what's your

I asked the patients uh what's your level of stress? And it's unbelievable.

level of stress? And it's unbelievable. There is no patients that were happy uh

There is no patients that were happy uh calm and happy when they got sick. It's

calm and happy when they got sick. It's unbelievable. Yeah.

unbelievable. Yeah. Uh and uh when they uh got sick, they

Uh and uh when they uh got sick, they were facing a stressful life event that

were facing a stressful life event that was um much higher than the stressful

was um much higher than the stressful life events that they used to face in

life events that they used to face in their in their lives. Uh so when they

their in their lives. Uh so when they start when they have the first

start when they have the first appointment, this is another question

appointment, this is another question that I ask right now. What is your level

that I ask right now. What is your level of stress in that scale from 0 to 10?

of stress in that scale from 0 to 10? because they were when they come back

because they were when they come back I'll ask them

I'll ask them again to see if they could decrease the

again to see if they could decrease the level of stress and uh if they could not

level of stress and uh if they could not decrease the level of stress I will

decrease the level of stress I will reinforce the importance of this in

reinforce the importance of this in order to uh live a normal life without

order to uh live a normal life without having to having to take high doses of

having to having to take high doses of vitamin D.

vitamin D. This is a really good point and

This is a really good point and important to know about the Coinbra

important to know about the Coinbra protocol that it's not just about giving

protocol that it's not just about giving very high therapeutic doses of vitamin

very high therapeutic doses of vitamin D. It's adjusting lifestyle

D. It's adjusting lifestyle um in terms of exercise, emotional

um in terms of exercise, emotional health, um and diet um

health, um and diet um and all of those. Wow. Wow. So you can

and all of those. Wow. Wow. So you can actually get them off of the therapeutic

actually get them off of the therapeutic vitamin D if they can control their

vitamin D if they can control their stress. That's pretty phenomenal.

stress. That's pretty phenomenal. Yes, they can. But sometimes there are

Yes, they can. But sometimes there are patients that are unable to control

patients that are unable to control their stress no matter uh how much you

their stress no matter uh how much you talk about. uh and

talk about. uh and uh uh but we are always trying in every

uh uh but we are always trying in every appointments and I would say that most

appointments and I would say that most patients are now uh realizing how

patients are now uh realizing how important this is for the success of the

important this is for the success of the treatment. Mhm. Do you utilize any other

treatment. Mhm. Do you utilize any other um nutrients or interventions to

um nutrients or interventions to specifically address stress for those

specifically address stress for those individuals who have a hard time just

individuals who have a hard time just controlling their behavior? Alpha has

controlling their behavior? Alpha has this effect. What was it? Magnesium

this effect. What was it? Magnesium itself has this effect. So the dose of

itself has this effect. So the dose of magnesium is adjusted according to the

magnesium is adjusted according to the maximum dose that a patient can have can

maximum dose that a patient can have can take without having diarrhea.

take without having diarrhea. uh so in in it's important to say that

uh so in in it's important to say that some uh magnesium salts are not suitable

some uh magnesium salts are not suitable for any treatment like that for for

for any treatment like that for for instance magnesium oxide cause a lot of

instance magnesium oxide cause a lot of diarrhea should never be taken be used

diarrhea should never be taken be used as a magnesium supplement for those

as a magnesium supplement for those reasons uh

reasons uh because most of the magnesium oxide are

because most of the magnesium oxide are not absorbed they remain

not absorbed they remain in the balls within the balls and the

in the balls within the balls and the high level high concentrations of a

high level high concentrations of a magnesium in the balls cause diarrhea.

magnesium in the balls cause diarrhea. So we use other types of

So we use other types of magnesium compounds

magnesium compounds like magnesium glyine, glycine,

like magnesium glyine, glycine, magnesium glycine,

magnesium glycine, um um magnesium

um um magnesium 308. Um you use citrate or um No, I

308. Um you use citrate or um No, I don't use citrate.

don't use citrate. Citrate increases the absorption of

Citrate increases the absorption of aluminum in our in our food. So aluminum

aluminum in our in our food. So aluminum is a terrible me metal. So I don't use

is a terrible me metal. So I don't use citrate.

citrate. Uh

Uh um so citrate is avoided and alum and

um so citrate is avoided and alum and magnesium magnesium oxide is avoided

magnesium magnesium oxide is avoided should be

should be avoided and we adjust the dose as I as I

avoided and we adjust the dose as I as I told you we adjust the dosing according

told you we adjust the dosing according to the bowel movements. The patient

to the bowel movements. The patient should be uh having bowel movements

should be uh having bowel movements every day at least once once a day but

every day at least once once a day but without their rear. If they are not uh

without their rear. If they are not uh having bowel movements every day, they

having bowel movements every day, they should increase the dose of magnesium.

should increase the dose of magnesium. If they are if they are if they have

If they are if they are if they have diarrhea, they should decrease the the

diarrhea, they should decrease the the dose of magnesium. So magnesium is

dose of magnesium. So magnesium is giving us a wedding within uh uh multi-

giving us a wedding within uh uh multi- uh multi

uh multi multivitamin supplement that I give the

multivitamin supplement that I give the patients.

patients. just the the

just the the basic daily dose of magnesium which

basic daily dose of magnesium which should be around 100 milligrams of

should be around 100 milligrams of magnesium three to four times per day

magnesium three to four times per day within that poly vitamin compound but I

within that poly vitamin compound but I give an additional magnesium uh to

give an additional magnesium uh to adjust the dose according to the bowel

adjust the dose according to the bowel movements. So uh literature related to

movements. So uh literature related to magnesium supplementation says that you

magnesium supplementation says that you have to adjust the dose according to

have to adjust the dose according to bowel

bowel movements. Okay. So I think this is

movements. Okay. So I think this is really important to say but uh some

really important to say but uh some other supplements can uh uh can u can

other supplements can uh uh can u can cause uh um can reduce the stress. One

cause uh um can reduce the stress. One of the supplements that can reduce

of the supplements that can reduce stress is glycine. Glycine is amino acid

stress is glycine. Glycine is amino acid and it can reduce stress. So we used to

and it can reduce stress. So we used to use magnesium glycine as a

use magnesium glycine as a preferential form of magnesium. But if I

preferential form of magnesium. But if I want to have more effects in the central

want to have more effects in the central nervous system, I might use magnesium

nervous system, I might use magnesium [Music]

[Music] umate.

Um if I want to to increase the release of uh

to increase the release of uh um the if I want to de detoxify

um the if I want to de detoxify um aluminum. Aluminum today is a major

um aluminum. Aluminum today is a major major uh

major uh concern of of ours in this protocol

concern of of ours in this protocol because we are seeing a lot of patients

because we are seeing a lot of patients with uh

with uh with problems related to aluminum. But

with problems related to aluminum. But we can get back to this uh

we can get back to this uh subject in a while if you want. Yes, I

subject in a while if you want. Yes, I would like that. Yeah. Okay. Would you

would like that. Yeah. Okay. Would you like to continue? Um, I I had a few

like to continue? Um, I I had a few other questions about other co-utrients,

other questions about other co-utrients, but I don't know if you're already um

but I don't know if you're already um planning on getting there. Um, for

planning on getting there. Um, for example, you talked about the B2. Um,

example, you talked about the B2. Um, you've also mentioned omega-3s, and then

you've also mentioned omega-3s, and then a lot of people ask about vitamin K. Um,

a lot of people ask about vitamin K. Um, and there's questions about vitamin A.

and there's questions about vitamin A. So, if you want to save those for later.

So, if you want to save those for later. No, I can answer now. Okay. Okay. by

No, I can answer now. Okay. Okay. by one. The first one would be

one. The first one would be Well, let me rewind a little bit and ask

Well, let me rewind a little bit and ask you uh because I think there's a

you uh because I think there's a misconception that taking very high

misconception that taking very high doses or or just just high doses, not

doses or or just just high doses, not even therapeutic doses of vitamin D can

even therapeutic doses of vitamin D can induce deficiency of another um

induce deficiency of another um nutrient. But the way that um I like to

nutrient. But the way that um I like to refer to it or or several of our other

refer to it or or several of our other scientists have referred to it is that

scientists have referred to it is that um is that correcting vitamin D

um is that correcting vitamin D deficiency and taking you know that

deficiency and taking you know that 10,000 IU of vitamin D a day as the high

10,000 IU of vitamin D a day as the high dose um simply reveals inadequacies of

dose um simply reveals inadequacies of other related nutrients. So, it's not

other related nutrients. So, it's not necessarily causing another nutrient

necessarily causing another nutrient such as magnesium or any of the B

such as magnesium or any of the B vitamins to become deficient. It's it's

vitamins to become deficient. It's it's just showing that they're already uh the

just showing that they're already uh the intake is already too low to support

intake is already too low to support normal function. Would you agree with

normal function. Would you agree with that? Or are there any specific

that? Or are there any specific nutrients that you also concern yourself

nutrients that you also concern yourself with when you're putting your patients

with when you're putting your patients on higher vitamin D?

on higher vitamin D? Well, I I try to increase

Well, I I try to increase the the capacity of fighting

the the capacity of fighting inflammation in my patients. So, omega-3

inflammation in my patients. So, omega-3 that you have mentioned is part of our

that you have mentioned is part of our protocol. So, we we give them omega-3

protocol. So, we we give them omega-3 high concentrated omega-3 times per day

high concentrated omega-3 times per day as part of our protocol. So they will

as part of our protocol. So they will produce their own anti-

produce their own anti- anti-inflammatory

anti-inflammatory uh

uh substances. regarding uh vitamin K2, we

substances. regarding uh vitamin K2, we uh several years ago, I would say like

uh several years ago, I would say like 15 years ago,

15 years ago, uh we tried to give to give vitamin K K2

uh we tried to give to give vitamin K K2 S MK7

S MK7 uh to try to prevent the loss of calcium

uh to try to prevent the loss of calcium in the bones of patients with uh uh with

in the bones of patients with uh uh with under high doses of vitamin D.

under high doses of vitamin D. under our protocol but it was useless.

under our protocol but it was useless. This did this did not work. So it it

This did this did not work. So it it only uh made the protocol more

only uh made the protocol more expensive. So I gave up using vitamin K2

expensive. So I gave up using vitamin K2 when you didn't see any buildup of

when you didn't see any buildup of calcium in the arteries or any other

calcium in the arteries or any other tissues that it wasn't supposed to be.

tissues that it wasn't supposed to be. If you keep the the calcium level

If you keep the the calcium level circulating calcium level within the

circulating calcium level within the normal range there is no r there is no

normal range there is no r there is no reason to be concerned about

reason to be concerned about calcification of

calcification of tissues. tissues may calcificate if you

tissues. tissues may calcificate if you have high levels of calcium in your

have high levels of calcium in your circulation. Uh so uh I try I I keep the

circulation. Uh so uh I try I I keep the the the level of calcium within the

the the level of calcium within the normal range.

normal range. uh by using the diet and other measures

uh by using the diet and other measures u

u but but I don't use vitamin K2

but but I don't use vitamin K2 um it it it sound I I understood that it

um it it it sound I I understood that it was useless it did not change anything

was useless it did not change anything laboratory test bone mass were not

laboratory test bone mass were not changed

changed um

um so what else would you like to ask

so what else would you like to ask regarding that those additional

regarding that those additional supplements. Um, do you put all of your

supplements. Um, do you put all of your patients on B2 and other B

patients on B2 and other B vitamins? And, uh, for how long?

vitamins? And, uh, for how long? Uh, well, as I showed you, uh, like 10%

Uh, well, as I showed you, uh, like 10% of the world

of the world population cannot absorb vitamin B2

population cannot absorb vitamin B2 completely, do not absorb properly.

completely, do not absorb properly. So I keep this high dose a high dose of

So I keep this high dose a high dose of of riboplavin which could be something

of riboplavin which could be something between 50 migs to 100 milligrams three

between 50 migs to 100 milligrams three or four times per day. uh to make sure

or four times per day. uh to make sure that all those patients uh who are who

that all those patients uh who are who have problems related to their

have problems related to their absorption of vitamin B2 will have the

absorption of vitamin B2 will have the benefit of receiving vitamin B2 in a

benefit of receiving vitamin B2 in a larger doses that would overcome their

larger doses that would overcome their poor ability poor absorption intestinal

poor ability poor absorption intestinal absorption of uh

absorption of uh of vitamin B2. So it's so important for

of vitamin B2. So it's so important for that reason that I showed you in in my

that reason that I showed you in in my in another slide. Vitamin B2 forms of

in another slide. Vitamin B2 forms of vitamin B2 is required for that

vitamin B2 is required for that auxiliary enzyme uh that is necessary

auxiliary enzyme uh that is necessary for the function of the vitamin D

for the function of the vitamin D hydroxyasis.

hydroxyasis. Um, so this is something important.

Um, so this is something important. Magnesium, magnesium and vitamin B2

Magnesium, magnesium and vitamin B2 uh should be given to all our

uh should be given to all our patients at least those two additional

patients at least those two additional supplements. But we also give uh we also

supplements. But we also give uh we also give u omega-3 high concentration

give u omega-3 high concentration omega-3. I I I I also give me that's

omega-3. I I I I also give me that's important. I also give them um meth

important. I also give them um meth methylolate

methylolate and vit vitamin B12

and vit vitamin B12 because lots of those patients

because lots of those patients have abnormalities related to folate

have abnormalities related to folate cycle and fate cycle is important for

cycle and fate cycle is important for such a large amount of uh of functions

such a large amount of uh of functions biochemical reactions in our organism

biochemical reactions in our organism including the production of a

including the production of a glutathione. So we depend on a good

glutathione. So we depend on a good folate cycle to produce glutathione

folate cycle to produce glutathione which is the main

which is the main uh

antioxidant antioxidant antioxidant mechanism in our organism

antioxidant mechanism in our organism the main

antioxidant defense in our organism. So I try to provide vitamin B12 and

I try to provide vitamin B12 and methylate never use folic acid. Folic

methylate never use folic acid. Folic acid should be should never be used

acid should be should never be used should never be administered to any

should never be administered to any patient because like 30% of the whole

patient because like 30% of the whole population will be will have problems

population will be will have problems related to uh the administration of

related to uh the administration of folic acid. Folic acid is not the normal

folic acid. Folic acid is not the normal vitamin B9 that is available in nature.

vitamin B9 that is available in nature. It's produced by pharmaceutical

It's produced by pharmaceutical companies as a folate that is resistance

companies as a folate that is resistance to heat. U but it should not be given uh

to heat. U but it should not be given uh to the whole population. No. and and

to the whole population. No. and and because like 30% of the whole the whole

because like 30% of the whole the whole population the whole world population

population the whole world population they had problems related to snips

they had problems related to snips related to uh folate metabolism. Uh I

related to uh folate metabolism. Uh I always give

always give them mythopolate always.

them mythopolate always. So it sounds like you are um you

So it sounds like you are um you individualize

individualize treatment to your patients specific

treatment to your patients specific needs. You adjust the co- nutrients

needs. You adjust the co- nutrients according to your patients individual

according to your patients individual needs.

needs. Yes, I do. But uh you're your question

Yes, I do. But uh you're your question is very important. I I'm always

is very important. I I'm always concerned to u keep myself

concerned to u keep myself uh in a good state of uh uh folate

uh in a good state of uh uh folate metabolism

metabolism um which is demonstrated by homocyine

um which is demonstrated by homocyine levels uh and it's a maj

levels uh and it's a maj major factor related to the elimination

major factor related to the elimination detoxification of metals like like

detoxification of metals like like anomal

anomal Alium is a major perhaps the major

Alium is a major perhaps the major health problems world health problem

health problems world health problem worldwide. Uh I'm not exaggerating. What

worldwide. Uh I'm not exaggerating. What I'm seeing is impressive.

I'm seeing is impressive. Yeah. And we'll talk more about that a

Yeah. And we'll talk more about that a little bit later, especially as it

little bit later, especially as it relates to autism. Um do you so you only

relates to autism. Um do you so you only measure the homoyine to get an idea of

measure the homoyine to get an idea of the the B vitamin snips or do you ever

the the B vitamin snips or do you ever do any genetic testing?

do any genetic testing? I measure on sustain uh especially in u

I measure on sustain uh especially in u um in people who

um in people who are who are older

are who are older than than 40 years old. Uh but I since I

than than 40 years old. Uh but I since I started

started uh treating uh pediatric patients with

uh treating uh pediatric patients with uh

uh um with autism ASD. I I was impressed to

um with autism ASD. I I was impressed to see that some of them have high levels

see that some of them have high levels of homocyine.

of homocyine. And the high homocyine is related to um

And the high homocyine is related to um which B vitamins is it just the folate

which B vitamins is it just the folate or is it also B12 or um

or is it also B12 or um maybe related to B12 and B9? B9 is the

maybe related to B12 and B9? B9 is the the methylopholate

the methylopholate but all you see vitamin B2 also plays a

but all you see vitamin B2 also plays a role in those fate cycles and magnesium

role in those fate cycles and magnesium also plays a role. So giving magnesium

also plays a role. So giving magnesium and giving vitamin B2

giving giving vitamin B12 and vitamin B9 in the form of

in the form of methylopholate are important

methylopholate are important uh items of uh of our protocol. Okay. Um

uh items of uh of our protocol. Okay. Um just a couple more questions on this

just a couple more questions on this topic because um the microbiome is an

topic because um the microbiome is an important piece in our overall health as

important piece in our overall health as well, especially when we're talking

well, especially when we're talking about autism. Do you ever address the

about autism. Do you ever address the microbiome as part of your protocols?

microbiome as part of your protocols? And I believe if you've got a healthy

And I believe if you've got a healthy microbiome, your your gut can actually

microbiome, your your gut can actually produce a lot of these B vitamins.

produce a lot of these B vitamins. I'm especially concerned about that when

I'm especially concerned about that when I treat patients with

I treat patients with ASD. But all in all patients, I advise

ASD. But all in all patients, I advise them to have a healthy diet that will

them to have a healthy diet that will because if your food is related to the

because if your food is related to the type of microorganisms that you have in

type of microorganisms that you have in your bowels, right, in your intestines.

your bowels, right, in your intestines. So I I suggest them to uh to decrease as

So I I suggest them to uh to decrease as much as possible uh the amount of meat

much as possible uh the amount of meat that they are eating

that they are eating um and uh change the source of proteins

um and uh change the source of proteins to vegetable sources of proteins and

to vegetable sources of proteins and eggs. If this is

eggs. If this is not sufficient then try to use fish

not sufficient then try to use fish other than other type of of

other than other type of of meat and sometimes yes I do

meat and sometimes yes I do supplement those patients with

supplement those patients with probiotics. It's a major concern of us.

probiotics. It's a major concern of us. Yeah. Right. One more question about

Yeah. Right. One more question about other nutrients because there are um

other nutrients because there are um certain groups that believe taking high

certain groups that believe taking high doses of vitamin D um can deplete your

doses of vitamin D um can deplete your vitamin

vitamin A. Do you ever concern yourself with

A. Do you ever concern yourself with vitamin A?

vitamin A? As you uh you are asking questions, I

As you uh you are asking questions, I I'm reviewing what I'm doing.

I'm reviewing what I'm doing. Yes, I it's I told you there is spoiler

Yes, I it's I told you there is spoiler alert.

alert. Yes. Uh do you remember that I told you

Yes. Uh do you remember that I told you that I I give patients a compound of

that I I give patients a compound of vitamins and vitamin A is included to

vitamins and vitamin A is included to that because uh in order to vitamin

D has it its actions at the level of vitamin D receptor within the nucleus.

vitamin D receptor within the nucleus. vitamin A will be

vitamin A will be required. So this is also added or a

required. So this is also added or a supplement of vitamin A

supplement of vitamin A like 500

like 500 micrograms three times per day is part

micrograms three times per day is part of our protocol nowadays. Maybe several

of our protocol nowadays. Maybe several years ago it was not but now it is.

years ago it was not but now it is. Okay. And we're talking retinol, right?

Okay. And we're talking retinol, right? Not the beta carotene the precursors.

Not the beta carotene the precursors. Sorry, we're talking the preform vitamin

Sorry, we're talking the preform vitamin A. Correct. Yes. Okay. Right. All right.

A. Correct. Yes. Okay. Right. All right. So, just to kind of wrap this little

So, just to kind of wrap this little part up, um, when we're

part up, um, when we're talking, you know, quote, high doses of

talking, you know, quote, high doses of vitamin D as in no more than 10,000 IU a

vitamin D as in no more than 10,000 IU a day, do we need to concern ourselves if,

day, do we need to concern ourselves if, you know, for example, if I take 5,000

you know, for example, if I take 5,000 IU of vitamin D a day, do I have to

IU of vitamin D a day, do I have to concern myself with these other

concern myself with these other nutrients? Um, if I don't have any

nutrients? Um, if I don't have any symptoms that reveal a current

symptoms that reveal a current inadequacy, will will taking that amount

inadequacy, will will taking that amount deplete or cause a deficiency of any of

deplete or cause a deficiency of any of these other nutrients that we've just

these other nutrients that we've just talked about by giving vitamin D? Yeah.

talked about by giving vitamin D? Yeah. 5,000 10,000 at most a day. This is you

5,000 10,000 at most a day. This is you produce that amount by exposing your

produce that amount by exposing your skin to sunlight.

skin to sunlight. Well, orally though, it's a little bit

Well, orally though, it's a little bit different. you know, our body's got

different. you know, our body's got built-in mechanisms with um how much

built-in mechanisms with um how much vitamin D we we produce. Um and it's,

vitamin D we we produce. Um and it's, you know, produced over a longer period

you know, produced over a longer period of time. But I I just want to address

of time. But I I just want to address this because there are certain people

this because there are certain people who are afraid to take oral vitamin D

who are afraid to take oral vitamin D because they've

because they've heard that it can create other

heard that it can create other deficiencies.

deficiencies. I have been using high doses of vitamin

I have been using high doses of vitamin D uh for more than 20 years

D uh for more than 20 years now and I did not have kind that kind of

now and I did not have kind that kind of problems in any patients and you can

problems in any patients and you can count thousand and thousands of patients

count thousand and thousands of patients that I have seen during this years. So

that I have seen during this years. So I'm really not concerned about this.

I'm really not concerned about this. what I told you uh th those supplements

what I told you uh th those supplements that I I told you about are those that I

that I I told you about are those that I we use. Um and that's it.

we use. Um and that's it. Thank you. All right. Well, I'll let you

Thank you. All right. Well, I'll let you carry on with your

carry on with your presentation. Thank you so much.

presentation. Thank you so much. Welcome.

Welcome. Um, okay. This uh slide shows that

Um, okay. This uh slide shows that vitamin D when you give doses like 1,000

vitamin D when you give doses like 1,000 units of vitamin D per day, your level

units of vitamin D per day, your level of vitamin D will essentially will not

of vitamin D will essentially will not change

change throughout say three, four or five

throughout say three, four or five months. Uh it must not it will not

months. Uh it must not it will not change

change significantly. Uh this graphic shows

significantly. Uh this graphic shows that even a daily dose of 1,000 units

that even a daily dose of 1,000 units will not significantly change the

will not significantly change the circuline levels of vitamin D after

circuline levels of vitamin D after several months of

several months of supplementation. Taking 1,00 units of

supplementation. Taking 1,00 units of vitamin D may be regarded as a high dose

vitamin D may be regarded as a high dose uh just because the M the Institute of

uh just because the M the Institute of Medicine recommends only 600 units per

Medicine recommends only 600 units per day and this is nothing. 600 units per

day and this is nothing. 600 units per day is

day is nothing. The graphic also shows that

nothing. The graphic also shows that when you give 10,000 units of vitamin D

when you give 10,000 units of vitamin D per day, which is uh no adverse effect

per day, which is uh no adverse effect uh

uh level, uh you will reach 800 nanogs per

level, uh you will reach 800 nanogs per mill, which is equivalent to

mill, which is equivalent to 200 nanomles per liter. And this is

200 nanomles per liter. And this is completely normal. You can't have if you

completely normal. You can't have if you are not resistant to vitamin D, you will

are not resistant to vitamin D, you will not have the full effect of vitamin D uh

not have the full effect of vitamin D uh with the levels before below 60 nanogs

with the levels before below 60 nanogs per ml or 150 nanom moles per liter. Um

per ml or 150 nanom moles per liter. Um uh people who

uh people who uh with low levels with low body weight

uh with low levels with low body weight may achieve levels significantly higher

may achieve levels significantly higher than that by higher than uh 80 niggs per

than that by higher than uh 80 niggs per milll by taking 10,000 units of vitamin

milll by taking 10,000 units of vitamin D per day but it

D per day but it it's still no it's it's still no adverse

it's still no it's it's still no adverse effect level.

effect level. [Music]

[Music] Um vitamin D is a fat soluble steroid

Um vitamin D is a fat soluble steroid and fat tissues act as a sponge a kind

and fat tissues act as a sponge a kind of sponge. So absorbing vitamin D from

of sponge. So absorbing vitamin D from from the

from the circulation. Therefore a p in a person

circulation. Therefore a p in a person with increased fat tissue the daily

with increased fat tissue the daily requirement of vitamin D needed to

requirement of vitamin D needed to achieve this its biological effect uh

achieve this its biological effect uh effects also has to be increased. Some

effects also has to be increased. Some some people with obesity may have to to

some people with obesity may have to to take like 20 or

take like 20 or 25,000 units of vitamin D per day to

25,000 units of vitamin D per day to achieve this level of 80 nanogs per ml.

achieve this level of 80 nanogs per ml. uh as I told you uh in case of an

uh as I told you uh in case of an emergency like during an epidemic or the

emergency like during an epidemic or the pandemic that we experienced a few years

pandemic that we experienced a few years ago uh an initial dose of 600,000 units

ago uh an initial dose of 600,000 units of vitamin D should be given orally and

of vitamin D should be given orally and uh depending on the body weight of that

uh depending on the body weight of that person it should it could be repeated in

person it should it could be repeated in the next day to achieve the uh the

the next day to achieve the uh the desirable level of 18 nanogs per ml

desirable level of 18 nanogs per ml immediately. because it's an

immediately. because it's an emergency.

emergency. Um well I I already told you that I also

Um well I I already told you that I also considered an emergency uh patient with

considered an emergency uh patient with MS who is at risk of blindness

MS who is at risk of blindness u and then because of optical

u and then because of optical neuroids. Um we also treat

neuroids. Um we also treat uh patients uh with uh other kind other

uh patients uh with uh other kind other auto autoimmune disorders that may

auto autoimmune disorders that may um may lead to blindness like ovitis for

um may lead to blindness like ovitis for instance. Uh we also give doses of

instance. Uh we also give doses of vitamin D to those patients and I might

vitamin D to those patients and I might give

give a a loading dose like that to those

a a loading dose like that to those patients.

patients. Um so this is a u a way of

Um so this is a u a way of uh of uh classifying patients or

uh of uh classifying patients or classifying their their situation as an

classifying their their situation as an emergency or

emergency or not. So if it's an emergency we have to

not. So if it's an emergency we have to use high doses of vitamin D. So, but I

use high doses of vitamin D. So, but I would like to uh uh to emphasize this

would like to uh uh to emphasize this 1,000 units of vitamin D per day only a

1,000 units of vitamin D per day only a minor change in the level of vitamin D

minor change in the level of vitamin D as compared to someone who makes zero

as compared to someone who makes zero units per day. Um and uh the M advises

units per day. Um and uh the M advises 600 units per day. So uh we see that

600 units per day. So uh we see that this is an absurd and I don't understand

this is an absurd and I don't understand how this uh how this uh advice has

how this uh how this uh advice has remained for so many years in spite of

remained for so many years in spite of those publications like

those publications like that repeated

that repeated publications. So the importance of

publications. So the importance of vitamin D in pregnancy. I I saw that

vitamin D in pregnancy. I I saw that this was one of your questions and it's

this was one of your questions and it's one of my main concern also.

one of my main concern also. Um vitamin D has numerous uh effects in

Um vitamin D has numerous uh effects in pregnancy.

pregnancy. uh it's sufficient to say as a pre

uh it's sufficient to say as a pre preliminary information that v vitamin D

preliminary information that v vitamin D is uh activated in the placenta both in

is uh activated in the placenta both in the uh maternal side of placenta and in

the uh maternal side of placenta and in the fetal side of placenta. It is the

the fetal side of placenta. It is the the placenta expresses that one alpha

the placenta expresses that one alpha hydroxilase enzyme that turns vitamin D

hydroxilase enzyme that turns vitamin D into uh 25 hydroxy into the active form

into uh 25 hydroxy into the active form one 25 hydroxyd and this has antimicrob

one 25 hydroxyd and this has antimicrob micro

micro miobial microbial and

miobial microbial and anti-inflammatory effects.

anti-inflammatory effects. um it will uh prevent u prevent

um it will uh prevent u prevent miscarriage due to autoimmune aggression

miscarriage due to autoimmune aggression against the f fetal tissues.

against the f fetal tissues. So the same article that I had was

So the same article that I had was mentioning here by Leo and

mentioning here by Leo and Hson also uh showed all those uh

Hson also uh showed all those uh situations that you may have if you have

situations that you may have if you have low levels of vitamin D during

low levels of vitamin D during pregnancy.

pregnancy. And I

And I would I would emphasize the maternal

would I would emphasize the maternal fetal HIV transfer or is multiple

fetal HIV transfer or is multiple scarosis later on in this individual

scarosis later on in this individual life. uh type the risk of diabetes uh uh

life. uh type the risk of diabetes uh uh in childhood if the the mother had low

in childhood if the the mother had low levels of vitamin vitamin D during

levels of vitamin vitamin D during pregnancy and

pregnancy and asthma and all those uh those

asthma and all those uh those complications in pregnancy you may have

complications in pregnancy you may have uh if you have low levels of vitamin D

uh if you have low levels of vitamin D you're in pregnancy so you can imagine

you're in pregnancy so you can imagine uh how much problems you may the number

uh how much problems you may the number the amazing number of problems

the amazing number of problems you you can prevent by just giving uh a

you you can prevent by just giving uh a pregnant woman an amount of 7,000 units

pregnant woman an amount of 7,000 units of vitamin D per day which is completely

of vitamin D per day which is completely safe.

safe. Uh it's important to say that some of

Uh it's important to say that some of our patients

our patients uh MS patients for instance who were

uh MS patients for instance who were unable to get pregnant when they started

unable to get pregnant when they started receiving high doses of vitamin D they

receiving high doses of vitamin D they get got pregnant within a few months. So

get got pregnant within a few months. So uh and you have vitamin D and fertility

uh and you have vitamin D and fertility you have like more than seven 70,000

you have like more than seven 70,000 papers published related to that.

papers published related to that. um uh as a neurologist I'm I'm I'm

um uh as a neurologist I'm I'm I'm really concerned about uh fetal brain

really concerned about uh fetal brain development and I see that patients who

development and I see that patients who are having 7,000 to 10,000 units or even

are having 7,000 to 10,000 units or even the high doses of vitamin D as we use in

the high doses of vitamin D as we use in our protocol they uh the the neuro neuro

our protocol they uh the the neuro neuro development of those children are

development of those children are amazing is amazing amazing

amazing is amazing amazing uh they are not only have a high

uh they are not only have a high IQ they are happy child children

IQ they are happy child children uh it's amazing they are completely

uh it's amazing they are completely different to children

different to children uh

uh so I I'm always wondering what will

so I I'm always wondering what will happen with humankind when the uh the

happen with humankind when the uh the advice of giving 10,000 or at least

advice of giving 10,000 or at least 7,000 units of vitamin D during

7,000 units of vitamin D during pregnancy. What will happen with

pregnancy. What will happen with humanity? Because we we'll have a

humanity? Because we we'll have a completely different kind of human

completely different kind of human beings as I'm I have seen during this uh

beings as I'm I have seen during this uh this 20 years when I started using this

this 20 years when I started using this protocol.

protocol. [Music]

[Music] Um but I uh I have to say that this uh

Um but I uh I have to say that this uh benefit may be lost during

benefit may be lost during uh due to uh administration of

uh due to uh administration of vaccines containing uh aluminum nanop

vaccines containing uh aluminum nanop particles in pregnancy and the large

particles in pregnancy and the large amount increasingly amount amounts of

amount increasingly amount amounts of vaccines that we are giving to children.

vaccines that we are giving to children. Okay. So, um I've been in touch with Dr.

Okay. So, um I've been in touch with Dr. Renu Matani who was also trained with

Renu Matani who was also trained with you and um I know she's training in

you and um I know she's training in India and I'm not sure about training in

India and I'm not sure about training in other parts of the world but would you

other parts of the world but would you encourage others to seek her and others

encourage others to seek her and others who are possibly also training the uh

who are possibly also training the uh other doctors in the coinber protocol to

other doctors in the coinber protocol to reach out to them. Yes, definitely Dr.

reach out to them. Yes, definitely Dr. Hanu Matani is a very clever and uh

Hanu Matani is a very clever and uh um efficient lady. She is doing a

um efficient lady. She is doing a wonderful work uh training other doctors

wonderful work uh training other doctors and I definitely need other doctors to

and I definitely need other doctors to train uh doctors so that uh I'm the I'm

train uh doctors so that uh I'm the I'm the only one in uh to be trained. I'm

the only one in uh to be trained. I'm the only one. I I don't I don't want to

the only one. I I don't I don't want to be the only one person training doctors

be the only one person training doctors in this so-called cobra protocol as the

in this so-called cobra protocol as the um as it's now known by by patients

um as it's now known by by patients definitely I would would encourage her

definitely I would would encourage her to continue. she's been in touch with me

to continue. she's been in touch with me uh because of that and I encou have and

uh because of that and I encou have and I have already encouraged her to go on

I have already encouraged her to go on with that activity.

with that activity. So she's got your full

So she's got your full support. That's good to know. One

support. That's good to know. One concern that she brought up and I'm

concern that she brought up and I'm curious if this is also a concern for

curious if this is also a concern for you in Brazil is that some doctors, some

you in Brazil is that some doctors, some practitioners who are doing the highdose

practitioners who are doing the highdose uh the therapeutic dose vitamin D um

uh the therapeutic dose vitamin D um there's some concern on their end for uh

there's some concern on their end for uh legal or lawsuits

legal or lawsuits um legal actions taken for uh patients

um legal actions taken for uh patients who do reach that toxicity.

who do reach that toxicity. Is that ever been a concern for you? um

Is that ever been a concern for you? um have you had to deal with that in your

have you had to deal with that in your practice or what is something that you

practice or what is something that you could uh tell doctors who are or do you

could uh tell doctors who are or do you already tell practitioners who are doing

already tell practitioners who are doing this uh to well uh you understand that

this uh to well uh you understand that we

we are facing um

are facing um opposition from from the medical

opposition from from the medical community

community um And it's been like that since we be

um And it's been like that since we be we started with this

we started with this protocol. But I have to deal with this.

protocol. But I have to deal with this. Um this is something that I it's part of

Um this is something that I it's part of my routine now. Um and

my routine now. Um and I what can I say? For instance, if you

I what can I say? For instance, if you go to the to the scholar Google and you

go to the to the scholar Google and you type a

type a migraine and you type a

migraine and you type a riboplavin, you will see that there are

riboplavin, you will see that there are thousands of publications showing

thousands of publications showing that high doses of riboplav hy

that high doses of riboplav hy riboflavin like 400 milligrams per day

riboflavin like 400 milligrams per day control

control migraine in 80% of cases. And if you

migraine in 80% of cases. And if you increase if you add magnesium to that

increase if you add magnesium to that treatment, you will reach close to 100%

treatment, you will reach close to 100% of cases under control.

of cases under control. And you see that there is um placebo

And you see that there is um placebo control

control groups, studies using placebo control

groups, studies using placebo control groups, randomized placebo control

groups, randomized placebo control groups, everything that is uh suggested

groups, everything that is uh suggested or indicated by the so-called

or indicated by the so-called evidencebased

evidencebased medicine. But there is not a single word

medicine. But there is not a single word uh about riboflavin in the textbook of

uh about riboflavin in the textbook of the medical doctor that treats migraine.

the medical doctor that treats migraine. So it's my opinion that uh

So it's my opinion that uh the transmission of knowledge within the

the transmission of knowledge within the medical community is under uh strict

medical community is under uh strict control. And it seems to me uh that any

control. And it seems to me uh that any kind of uh new

kind of uh new therapy that

therapy that is addressing the cause of diseases

is addressing the cause of diseases and

and uh carries the possibility of decreasing

uh carries the possibility of decreasing uh the commercialization the trade of uh

uh the commercialization the trade of uh of uh uh medicines. They are they seem

of uh uh medicines. They are they seem to be excluded from textbooks and uh

to be excluded from textbooks and uh medical meetings. So that it doesn't

medical meetings. So that it doesn't matter if you have thousands, tens of

matter if you have thousands, tens of thousands or hundreds of thousands of

thousands or hundreds of thousands of publications, they are not

publications, they are not mentioned.

mentioned. So I don't have anything to do about

So I don't have anything to do about that. I just have to keep my work do the

that. I just have to keep my work do the best I can for my

best I can for my patients. Um and when there

patients. Um and when there is when there is some uh litigations, I

is when there is some uh litigations, I have to try to uh to deal deal with that

have to try to uh to deal deal with that as as

as as in the best way I can but I cannot I

in the best way I can but I cannot I cannot be stressed because of that

cannot be stressed because of that because I know that stress triggers

because I know that stress triggers diseases

diseases so it really has to be part of the

so it really has to be part of the routine even Dr. Maktani has received

routine even Dr. Maktani has received criticisms from their pair her pairs. So

criticisms from their pair her pairs. So I think that this is expected. It's not

I think that this is expected. It's not something that you you should be

something that you you should be surprised to see about that. Um I maybe

surprised to see about that. Um I maybe in some countries like a

in some countries like a US the pressure on medical doctors may

US the pressure on medical doctors may be

be higher than in other countries.

higher than in other countries. um for obvious reasons uh most

um for obvious reasons uh most pharmaceutical companies are located

pharmaceutical companies are located there. Um but it's something it's a

there. Um but it's something it's a problem that we have to face

problem that we have to face because I bet you've probably

because I bet you've probably seen the amount of effectiveness that

seen the amount of effectiveness that comes from the use of therapeutic doses

comes from the use of therapeutic doses of vitamin D, how effective it is. And

of vitamin D, how effective it is. And I'm I'm assuming, correct me if I'm

I'm I'm assuming, correct me if I'm wrong, that it's probably safer than a

wrong, that it's probably safer than a lot of the pharmaceutical drugs on the

lot of the pharmaceutical drugs on the market for some of these diseases that

market for some of these diseases that you're treating with vitamin D. I'm sure

you're treating with vitamin D. I'm sure I'm sure about that. Yeah. Um the uh um

I'm sure about that. Yeah. Um the uh um the medicines that are sold to treat

the medicines that are sold to treat autoimmunity disorders are very

autoimmunity disorders are very expensive. Very very expensive.

expensive. Very very expensive. There is one medication for MS that five

There is one medication for MS that five tablets cost like

tablets cost like $46,000 in US.

$46,000 in US. So you can imagine what is happening

So you can imagine what is happening um when you what would happen when

um when you what would happen when someone tries to provide uh another

someone tries to provide uh another treatment that instead of causing

treatment that instead of causing depression of human system enhances the

depression of human system enhances the power of human immune system uh in

power of human immune system uh in fighting infection

fighting infection infections. Um and there is something

infections. Um and there is something else that I have to add some some

else that I have to add some some another information.

another information. uh most of when you when they say that

uh most of when you when they say that uh in order to be accepted by the

uh in order to be accepted by the medical medical community you have to

medical medical community you have to per perform a placebo controlled

per perform a placebo controlled um randomized randomized placebo

um randomized randomized placebo controlled study

controlled study multicentric the we don't have money to

multicentric the we don't have money to to make a multicentric study u I would

to make a multicentric study u I would never ask uh some relative of mine to to

never ask uh some relative of mine to to take part of a study like that using

take part of a study like that using just to prove that vitamin D given in

just to prove that vitamin D given in high doses controls those autoimmunity

high doses controls those autoimmunity disorders because I know that those

disorders because I know that those patients who fall in the control group

patients who fall in the control group will be damaged and will de damaged

will be damaged and will de damaged forever. So I don't feel comfortable

forever. So I don't feel comfortable about that. I I would never do that. Um

about that. I I would never do that. Um and another issue is that uh this type

and another issue is that uh this type of study is uh is uh

of study is uh is uh impossible it's not it would not be

impossible it's not it would not be blinded double

blinded double blinded because you have to adjust the

blinded because you have to adjust the dose according to the resistance of the

dose according to the resistance of the patient. So you have to see uh the

patient. So you have to see uh the laboratory results and uh and adjust the

laboratory results and uh and adjust the dose according to uh to that those

dose according to uh to that those laboratory results. So that's not uh

laboratory results. So that's not uh that's not uh possible um uh in terms of

that's not uh possible um uh in terms of placebo control studies, double blind

placebo control studies, double blind placebo control studies, right? So uh

placebo control studies, right? So uh that's it. Uh we have to go on and do as

that's it. Uh we have to go on and do as as much benefit to our patients as

as much benefit to our patients as possible. Yeah. Yeah. And in the

possible. Yeah. Yeah. And in the meantime, um, you know, those who do

meantime, um, you know, those who do take this into practice, um, can rely on

take this into practice, um, can rely on other doctors like you, Dr. Matani, and

other doctors like you, Dr. Matani, and the many very knowledgeable vitamin D

the many very knowledgeable vitamin D researchers such as those on the

researchers such as those on the grassroots health panel. Um, we've got a

grassroots health panel. Um, we've got a great community of of individuals who

great community of of individuals who are well aware of of what's going on.

are well aware of of what's going on. Uh, Dr. William Grant, for example,

Uh, Dr. William Grant, for example, wrote the vitamin D misinformation

wrote the vitamin D misinformation playbook, and he talks about this a lot.

playbook, and he talks about this a lot. Um, and you just can't let that scare

Um, and you just can't let that scare you and just have faith that this

you and just have faith that this uh this really does work. Yes. Some

uh this really does work. Yes. Some other doctors that were trained in our

other doctors that were trained in our clinic also have published about the

clinic also have published about the safety of

safety of uh of cobbra protocol and they

uh of cobbra protocol and they have uh other doctors like uh those were

have uh other doctors like uh those were I guess it was from Germany. They they

I guess it was from Germany. They they produced two

produced two papers and there is another paper

papers and there is another paper published by by Italian groups of

published by by Italian groups of medical doctors

medical doctors u showing the improvement of

u showing the improvement of uh of quality of life

uh of quality of life those patients having uh under high

those patients having uh under high doses of vitamin D. So I know I'm glad

doses of vitamin D. So I know I'm glad to see that other doctors are planning

to see that other doctors are planning to uh publish that because I cannot do

to uh publish that because I cannot do everything on my own. I need

everything on my own. I need cooperation.

cooperation. That brings me to a question that one of

That brings me to a question that one of our sc our doctors uh sent me and I hope

our sc our doctors uh sent me and I hope you don't mind my asking you now. Uh but

you don't mind my asking you now. Uh but Dr. Patrick Nolo has published um

Dr. Patrick Nolo has published um several papers. Um he is a medical

several papers. Um he is a medical doctor. He's been using high doses of

doctor. He's been using high doses of vitamin D in with all of his patients um

vitamin D in with all of his patients um in the hospital that he works at and he

in the hospital that he works at and he was wondering if you would be willing to

was wondering if you would be willing to collaborate with him um

collaborate with him um on uh treating patients with Parkinson's

on uh treating patients with Parkinson's disease. uh that is one of the things

disease. uh that is one of the things that he would like to speak with you

that he would like to speak with you about uh the the therapeutic doses of

about uh the the therapeutic doses of vitamin D on Parkinson's and um and then

vitamin D on Parkinson's and um and then publish okay I'm glad that you asked

publish okay I'm glad that you asked that question I'm open to cooperate with

that question I'm open to cooperate with any doctor any physician but I have to

any doctor any physician but I have to say that Parkinson's disease is not auto

say that Parkinson's disease is not auto notimmune disorder and we don't use uh

notimmune disorder and we don't use uh this highdose vitamin D protocol in

this highdose vitamin D protocol in Parkinson's disease uh Parkinson's

Parkinson's disease uh Parkinson's disease is one of the most uh

disease is one of the most uh uh cases of diseases that we see um very

uh cases of diseases that we see um very very high level of stress in those

very high level of stress in those patients. Uh they have ever

patients. Uh they have ever been extremely worried about all

been extremely worried about all problems that they face. They are highly

problems that they face. They are highly responsible people.

responsible people. uh they don't want they don't accept or

uh they don't want they don't accept or they don't want to

they don't want to accept that uh things uh are not

accept that uh things uh are not under possible bad the the outcomes of

under possible bad the the outcomes of the problems that they they're facing

the problems that they they're facing escape their control. They're trying to

escape their control. They're trying to control everything. They're afraid of

control everything. They're afraid of things that they may happen. they they

things that they may happen. they they think about every possible outcome of

think about every possible outcome of any problem they are are facing. This is

any problem they are are facing. This is a this is essentially the the

a this is essentially the the personality that is seen in this in

personality that is seen in this in almost 100% of patients with Parkinson's

almost 100% of patients with Parkinson's disease and we have been dealing with

disease and we have been dealing with Parkinson's disease but trying to change

Parkinson's disease but trying to change that personality.

that personality. uh of course we give vitamin

uh of course we give vitamin D not in high doses what I call high do

D not in high doses what I call high do I don't I'm not sure uh what you are

I don't I'm not sure uh what you are calling high doses in in your question

calling high doses in in your question but I'm I'm giving like a 10 15,000

but I'm I'm giving like a 10 15,000 units of vitamin D to patients with

units of vitamin D to patients with Parkinson's disease

Parkinson's disease uh because uh several years ago I tried

uh because uh several years ago I tried to give them high doses of vitamin D and

to give them high doses of vitamin D and I felt it did not work. Um so we are

I felt it did not work. Um so we are trying other measures uh uh to decrease

trying other measures uh uh to decrease the the the activity of that disease

the the the activity of that disease uh like giving glycine in high doses of

uh like giving glycine in high doses of glycine which is an amino acid uh that

glycine which is an amino acid uh that decreases that causes

decreases that causes calmness in calmness. we are associated

calmness in calmness. we are associated with associating that with any cysteine

with associating that with any cysteine also it seems to be working in the first

also it seems to be working in the first few patients I hope that impression goes

few patients I hope that impression goes goes on but uh Parkinson's disease is

goes on but uh Parkinson's disease is not an autoimmune disorder and I guess

not an autoimmune disorder and I guess that this this confusion came from the

that this this confusion came from the fact that patient that doctors that were

fact that patient that doctors that were here to be trained on high doses of

here to be trained on high doses of vitamin D as a because I'm I'm a

vitamin D as a because I'm I'm a neurologist I is also seen patients with

neurologist I is also seen patients with Parkinson lots of patients with

Parkinson lots of patients with Parkinson's and maybe there isn't this

Parkinson's and maybe there isn't this impression that uh uh Parkinson's

impression that uh uh Parkinson's disease is uh uh Parkinson's diseases

disease is uh uh Parkinson's diseases respond to high doses of vitamin D

respond to high doses of vitamin D that's not my impression but we we we

that's not my impression but we we we correct the level of vitamin D in those

correct the level of vitamin D in those patients too because because of the

patients too because because of the effects of vitamin D has in the central

effects of vitamin D has in the central nervous system in the brain brain

nervous system in the brain brain inducing um neurotrophic factors that

inducing um neurotrophic factors that increase the life lifespan of neurons.

increase the life lifespan of neurons. So

So uh that's what I I have to say about

uh that's what I I have to say about that. No other information I have

that. No other information I have available for the practitioners who are

available for the practitioners who are interested in going through the training

interested in going through the training for the Coinbra protocol. I really

for the Coinbra protocol. I really wanted you to share a little bit more

wanted you to share a little bit more about what's involved with that. Um, I

about what's involved with that. Um, I know I sent some questions from our own

know I sent some questions from our own scientist panel and some of the other

scientist panel and some of the other doctors in our network, but I would like

doctors in our network, but I would like to just kind of turn the conversation

to just kind of turn the conversation from that for the general public to

from that for the general public to those who are in the medical field who

those who are in the medical field who might want to come and learn more from

might want to come and learn more from you.

you. So, you are asking about the training of

So, you are asking about the training of other doctors. Is that what you mean?

other doctors. Is that what you mean? Yeah, I sent some questions.

Yeah, I sent some questions. um for uh about the training and the

um for uh about the training and the protocol such as uh what is the cost of

protocol such as uh what is the cost of participation and what is the curriculum

participation and what is the curriculum um how many hours does it take

um how many hours does it take um you know if you could just kind of

um you know if you could just kind of share a little bit about what is

share a little bit about what is expected for those who want to be

expected for those who want to be trained because we don't have enough

trained because we don't have enough coin uh protocol practitioners in the

coin uh protocol practitioners in the United States so

United States so You have five of them. I I trained five

You have five of them. I I trained five uh medical doctors.

uh medical doctors. Um I think that four uh medical doctors

Um I think that four uh medical doctors and a lady osteopathic lady that works

and a lady osteopathic lady that works in that work in US. I'm not I'm not sure

in that work in US. I'm not I'm not sure how many of them are still working. U um

how many of them are still working. U um I have received uh messages only from a

I have received uh messages only from a few of them but we never charged

few of them but we never charged anything for patient for medical doctors

anything for patient for medical doctors who came to Brazil to uh to have a

who came to Brazil to uh to have a period of training. Uh this uh usually

period of training. Uh this uh usually takes a week um actually five days on

takes a week um actually five days on Monday to Friday. uh they uh they see me

Monday to Friday. uh they uh they see me um treating patients and they ask

um treating patients and they ask questions uh and I respond to those

questions uh and I respond to those questions

questions uh as deeply as I can. Uh but there is

uh as deeply as I can. Uh but there is no no charge they have to only to deal

no no charge they have to only to deal with the travel uh expenses or hotel

with the travel uh expenses or hotel expenses but not uh nothing is charged

expenses but not uh nothing is charged uh by myself. I don't charge anything

uh by myself. I don't charge anything because for that I stopped the when I

because for that I stopped the when I stopped the training doctors uh uh

stopped the training doctors uh uh during the pandemic and I'm now planning

during the pandemic and I'm now planning to resume those trainings but I have to

to resume those trainings but I have to adjust my schedule to uh to resume that

adjust my schedule to uh to resume that that those trainings because you see you

that those trainings because you see you have a patient in the in the room you

have a patient in the in the room you have myself you have one or two

have myself you have one or two sometimes sometimes three doctors asking

sometimes sometimes three doctors asking question questions

question questions uh at the same time when I'm seeing

uh at the same time when I'm seeing those patients and prescribing to those

those patients and prescribing to those patients but I I try to do as much as I

patients but I I try to do as much as I can um is there any other question that

can um is there any other question that you had about that? Well, when uh do you

you had about that? Well, when uh do you have any idea when you're going to

have any idea when you're going to resume training and how will we know and

resume training and how will we know and then how would somebody get a hold of

then how would somebody get a hold of you to arrange to come and uh be a part

you to arrange to come and uh be a part of that? Maybe maybe in the second half

of that? Maybe maybe in the second half of this

of this year. There are several issues now going

year. There are several issues now going on uh in my professional life and uh uh

on uh in my professional life and uh uh related to that I'm receiving demands

related to that I'm receiving demands from from doctors who had a period of

from from doctors who had a period of training here and never every now and

training here and never every now and then they they ask questions about the

then they they ask questions about the cases that they are

cases that they are uh seeing. Uh but I trying to I'm trying

uh seeing. Uh but I trying to I'm trying to do the best that I can.

to do the best that I can. Okay. So they could email you and and

Okay. So they could email you and and arrange that when and then you'll be

arrange that when and then you'll be able to respond and um yeah there is a

able to respond and um yeah there is a during those five years there is a huge

during those five years there is a huge list of emails that have been sent

list of emails that have been sent asking for a period of training. But I'm

asking for a period of training. But I'm the only the only doctor in this clinic

the only the only doctor in this clinic that is providing this clinic in English

that is providing this clinic in English and so it's a lot of work. We need to

and so it's a lot of work. We need to train more trainers.

train more trainers. Train more

Train more trainers.

trainers. Yeah, but it has to be feasible too.

Yeah, but it has to be feasible too. One more curiosity before we move into

One more curiosity before we move into autism. Uh did you see a lower incidence

autism. Uh did you see a lower incidence of COVID um severe COVID uh COVID deaths

of COVID um severe COVID uh COVID deaths among your patients who were on the high

among your patients who were on the high doses of vitamin D, the therapeutic

doses of vitamin D, the therapeutic doses?

doses? In patients who had the who were

In patients who had the who were receiving high doses of vitamin D, none

receiving high doses of vitamin D, none of them had COVID. Wow.

of them had COVID. Wow. uh in patients who are receiving what I

uh in patients who are receiving what I consider the normal dose of vitamin D

consider the normal dose of vitamin D which is 10,000 units for someone who

which is 10,000 units for someone who has

has um a normal um body m body mass index

um a normal um body m body mass index u

u they they had only mild um

they they had only mild um manifestations of COVID there's a

manifestations of COVID there's a thousands of publications now showing

thousands of publications now showing that

that uh low levels of vitamin D are related

uh low levels of vitamin D are related to severe cases of of COVID and uh

to severe cases of of COVID and uh advising supplementation of COVID. when

advising supplementation of COVID. when the COVID 19 started in

the COVID 19 started in 2020,

2020, I advised I even recorded a clip that

I advised I even recorded a clip that went was published by one of my

went was published by one of my colleagues in the

Facebook in the Facebook um and he uh on that video clip I

um and he uh on that video clip I advised all patients to take 600,000

advised all patients to take 600,000 units of of vitamin

units of of vitamin immediately and started uh 10,000 units

immediately and started uh 10,000 units per day

per day afterwards.

afterwards. Um some patients that were on high doses

Um some patients that were on high doses of vitamin

of vitamin D and had their uh autoimmune disorder

D and had their uh autoimmune disorder under

under control. They had flares. MS patients

control. They had flares. MS patients had

had flares and new lesions when they took

flares and new lesions when they took those MR MRI vaccines.

those MR MRI vaccines. So

So um and that was a kind of disappointing

um and that was a kind of disappointing because

because um kind of disappointment because um

um kind of disappointment because um those were patients that were having a

those were patients that were having a normal life for like 10 years and then

normal life for like 10 years and then they they had those shots and then

they they had those shots and then suddenly they have a new flare, a new

suddenly they have a new flare, a new lesion, active lesion and we had to deal

lesion, active lesion and we had to deal with this and that caused us a lot of

with this and that caused us a lot of problems. That was one of the issues

problems. That was one of the issues that increased the amount of work and

that increased the amount of work and contributed to stop receiving uh order

contributed to stop receiving uh order doctors uh for a period of training in

doctors uh for a period of training in our clinic.

our clinic. [Music]

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YouTube Transcript:Vitamin D Therapy Explained by Dr. Cicero Coimbra | Benefits, Uses & Protocols

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Vitamin D Therapy Explained by Dr. Cicero Coimbra | Benefits, Uses & Protocols