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I switched from Ocrevus to Kesimpta. Here’s why. #MultipleSclerosis #msdiagnosis #multiplesclerosis | NeuroCliff | YouTubeToText
YouTube Transcript: I switched from Ocrevus to Kesimpta. Here’s why. #MultipleSclerosis #msdiagnosis #multiplesclerosis
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This video details a personal experience comparing two Multiple Sclerosis (MS) treatments, Ocrevus and Kesimpta, focusing on their pros, cons, and the author's eventual switch from Ocrevus to Kesimpta due to administration challenges and the "crap gap" phenomenon.
so this video is going to cover the pros
and cons I experienced with the switch
from ovisa senta and also what I'm
considering moving forward hi everyone
I'm Cliff and I have MS but first before
we get started here's a fun little fact
Germany has the highest rate of
diagnosed multiple sclerosis in the
world people really don't know why yet
though it could have something to do
with their
pretzels most importantly here I'm not a
doctor I'm not a clinician talk to your
doctor about all this stuff this is just
my experience and my perspective if you
are recently diagnosed and your doctor
has said it's time to make a decision
about which drug to take even though
this video is about someone who's been
on both drugs for almost 5 years I think
it's going to have a lot of valuable
information for you because looking back
I would have done things a little bit
differently when I started my drug
regimen for multiple sclerosis and we'll
talk about that so first off what's the
difference between okis and cassa well
there are a lot of differences
I think the biggest difference is the
delivery mechanism so with okis you go
into a clinic every six months and sit
there in an infusion chair they plug you
into an IV you have a clinical staff
there and you sit there from 4 to 6 to 7
hours while this stuff drips into your
system with centa it's basically a home
injection and if you get queasy at the
thought of doing your own
injections keep listening because I
really battled with that and I'll talk
about that later if you want to get kind
of nerdy with the science behind this
basically these two drugs block a cd20
protein here's a nice little
illustration on a scientific front that
Dr freehan allowed me to use thank you
Doctor both are CD monoclonal antibodies
meaning they target and deplete B cells
in the immune system thought to
contribute to Ms they do this in
slightly different ways but the end goal
is to Target the cd20 protein bind to it
and render it basically ineffective okay
so the administration of the drug is for
me was 7 hours with okris every 6 months
and it's about 5 seconds with cassa
every month so I started on okis in 2018
and what eventually ended up happening
is after 2 years I switched to cassa
because okis was not working for me and
what do I mean by okris not working for
me well it was working for me in
stopping the progression of disease but
all was not well in ois land and I'm
going to talk about the cons of my
experience with okis first of all the
lengthy Administration I don't like
sitting anywhere for 6 hours just not
comfortable sitting down so that was not
okay with also I just don't like needles
and IVs the prophylactic drug cocktail
which consisted of badril and Tylenol
and Zofran for the nausea plus two other
things I don't remember what they were I
think caused a lot of the side effects
the next day I mean you're unloading a
lot of crap in your system in one day
the crap Gap the crap Gap is basically
there's this time that after you get
your infusion where things seem to be
going swimming ly well and then it falls
off and you have to wait until your next
infusion for those things to resolve so
what I mean is my symptoms would really
be reduced during that first three
months remember this is a six month
infusion like you take it and then you
wait six months for the next one the
first three months were good the last
three months were terrible everything
came back and it was just miserable this
became a a constant I could set my watch
to it and and it's one of the main
reasons I started looking at other drugs
the side effects were pretty gnarly 3 or
4 days after the infusions just I just
felt crappy and like I said you're
putting a lot of drugs in your body in
one day the clinical scheduling may have
changed but back in 2018 2019 of course
covid started and getting into a clinic
um was just a hassle and uh which just
added another step to the process of
something I didn't want to do to begin
with all right let's talk about the
prosis Okay it definitely helped with
the symptoms for the first three months
of the infusion it definitely reduced
relapses um it definitely reduced
progression according to my
MRIs and uh the clinics had yummy snacks
and cozy lounge chairs so I mean the
drug was
effective I just don't know if it was
effective in reducing symptoms but they
never promised that they said they were
reducing progression and reducing
relapses so okis not bad but there's
better so then I moved on to cassa with
the idea that if I took cassa once a
month I'd have more regular dosing and I
wouldn't get the crap Gap because that
was my main complaint what are the cons
with cassa well finding a comfortable
injection site you know something that I
think everybody has to get used to I
initially ejected in my upper thigh like
they said on the brochures it was very
uncomfortable but I did find Place uh
around my abdomen that where's a little
bit of fat that I can inject into and I
really don't feel it so I'd say nine
times out of 10 is very tolerable at
this point you get better at it initial
dosing so initially you do one shot a
week for three weeks and then I think
you skip a month and then you start
doing your once a month thing that first
ramp up is a little much you're getting
used to a total lifestyle change where
you're now responsible for these drugs
and scheduling them yourself and doing
all that stuff and the side effects for
me were really gnarly after the first
few injections 3 days after I do my
injections I'm just not a very nice
person because I'm just very
uncomfortable but it fades quickly and
now as of the last two or three months
it has not been bad at all um I'm very
functional after my injection however
cassa in general just fatigues me a
little bit more I noticed um being
responsible for the drug well they ship
it right to your door you put it in your
refrigerator and it stays there
refrigerated until the day you take it
and you know for some people that's a
eight n $10,000 a month drug just having
it there in the refrigerator thinking
that someone could accidentally leave it
out or throw it away is uh you know it
definitely sits on my mind but I have a
special spot for in the refrigerator and
it's fine remembering to take it I'm
very OCD about my schedule stuff it's
not a problem for me but for someone
else that's not as OCD about their
schedule I think you know you take
something once a month um you better put
it in Google reminders because you're
going to forget the ramp up side effects
I talked a little bit about that my
first 3 to four months pretty rough for
the first 3 to 4 days after the
injections and then my body kind of got
used to it I think I don't know but it's
not nearly as bad anymore it's very
tolerable the pros of cempa well home
delivery right you're not scheduling
Clinic time which is awesome it
literally takes 5 Seconds to inject
which is awesome you have the rest of
your day you're not committing your day
to sitting in a clinic though eating the
cookies was kind of nice minimal side effects
effects
I've had and I put an aster next to that
because I think it changes for everybody
but after the fourth or fifth month for
me I'd have to say the side effects are
not bad not bad at all uh no
prophylactic cocktails I don't need to
take all those drugs like benad dril and
zofran and all that stuff prior to doing
the injection which is really nice
because I don't like taking that stuff
and so that's just one extra step I
don't have to remember to do and
something I don't have to be
uncomfortable about even though I hate
needles I hate IVs I hate all that stuff
it does get easier it getss easier to
give myself an injection every time and
now it's very easy but you know the
first time I did it it took me an hour
to convince myself so cassa wins out for
convenience and and not only that I
think my Ms feels a lot more manageable
at this point and I'm not experiencing
any crap gaps so that part's great I
hope you found this information helpful
please comment below if you have any
questions that I can answer again I'm
not a doctor I'm not a clinician I'm
just a random dude on YouTube with Ms
that's a patient and also takes
cinta click that subscribe if you don't
mind and hit that like button if you
enjoyed this stuff because I want to
make this channel a nice little
Community where we can share knowledge
and experiences not just around Ms but
life in general I appreciate you I'm
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