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development up to 3rd week trileminar disc part 2 360p

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This content details the complex process of gastrulation, specifically focusing on the formation and development of the notochord, which is crucial for establishing the central axis of the embryo and initiating the formation of major organ systems.

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so we were talking about the development

of the notochordal

system not according process so what up

to now what we discussed that all the

cells which are moving towards the

Primitive nodes they go down through the

Primitive tape and then they make a tube

and that tube extends from the Primitive

node forward up to the pro Cardinal

pre-cardial plate between the epiblast

and endoderm is that right and if you

make a section here right you will find

that this tube has

roof and floor the floor of the tube is

roof of the tube is in contact with

epiblast floor of the tube is in contact with

with

endoderm the floor of the tube and

endoderma cells longitudinal in a linear

fashion they disappear in this way

temporarily or transiently

amniotic fluid through the Primitive pad

through the what is this process

process

right and through the disintegrated notochordal

notochordal

process floor and disintegrated

endoderma area can communicate through

Yorkshire and this temporary

communication between the amniotic

cavity and the definitive joke Sac

through this area is called

neuro enteric Canal why it is called

neuron Terry Canal because later on you

will learn that this part of the yes

what is this

this will play a role in formation of

nervous system and this lowermost part

of the what is this endoderm that will

be playing a role in formation of an

enteric system enteric system in

gastrointestinal system so this tube

extends from that part of the embryonic

disc which is going to develop nervous

system up to that part of the embryonic

dust which is going to develop and

Terrace system so tube is called neuro

enteric canal

am I clear now

let us make a section like this

and see how nodochordal process is

developing now we are making transfer

section this was a longitudinal section right

right

so in transfer section what we are going

to do okay [Applause]

[Applause]

epiblast I've made here at the top there

epiblast cells right and here is your notocoidal

notocoidal

what is it

process or tube or notocardial canal

guess

endoderm developed and

yes my friends what is here mesoderm

right this is called intra embryonic

method because it is within the embryo

if you want to be really too good you

and of course there will be Pro chordal

plate here but anyway now

now

I told you this area you should

concentrate this is the floor of the new

notoral process right and this was the

endoderm now endoderm and

floor of this process right floor of the

and what is this endoderm they touch

each other and then disintegrate when

they disintegrate what happens

so this is now situation like this and

what is this

this is now roof and the sides of the notocoidal

notocoidal process

process

this all thing is called

now it will come down little bit and you

will find that in the next stage

the next stage I am going to draw the

epiblast or

process

you will find look these two part make

the connection what is with this endoderm

endoderm

mesoderm right now

this at this stage this notoconal

structure is called notochordal plate

because it's no motor tube is it a tube

no right so it is called notocoidal

played previously in the very beginning

and when it interculates neuron Terry

can all will disappear

are you understanding so it was

temporary or transient because this part

will come down and

make the Gap filling so what is this

notocoidal plate so notochordal tube

tube notocoidal

notocoidal

play it then funny thing will happen

these cells will proliferate a lot

and when they will proliferate a lot

they will undergo a change and after

a few days you will find

that these cells have again this neutral

control plate has detached separated or

detached from

endoderm and it has proliferated a lot

and now it make a mess of

solid mass of

right and they are separated from it

they have moved upward and

then endoderm from where they have

detached there was endoderm here isn't it

from where they have detached endoderm

right and what's here yes

measured on so what has happened first

there was notocordial tube lost the

floor of the notoriety tube with the

roof of the jock sat and roof of the

jock sack was

endoderm and then it notocordial tube

converted into notocardial plate and

then neutral notocardial plate

integrated with the endoderm then it

started proliferating and again

separated and move upward and endoderm

proliferate and fill the Gap and now

this this is is it a tube or this is a

solid rod

solid Rod this is called definitive Noto

card what is it called the definitive

Noto called is that right and so what

you will have that

you have definitive note card and later

on you will learn this definitive

notochord will play a very important role

role

in development of nervous system and

development of the other structures

around it for example definitive note

card will produce the product which will

force the cells of the ectoderm to

proliferate and make the neural plate

they will force mesodermal cell to

proliferate and make

what is this

parasial mesoderm we will talk about

these things later but one thing which

is very important about notochard the

notochord is a primitive structure which

start developing in the third week of the

the

development right and uh this determines

the central axis of the embryo right

around it with many structures will

develop and eventually notocar

disappears an adult person do you think

you have notocol Julio

you don't have not occurred yes

any one of you have some part of moto card

card

I think you have some anti-noto chord

attitude none of you have not a card

no all of us have some remnants or

remnants of notochord

let me tell you actually around the

notochord later on you will learn this

mesoderm will proliferate a lot and it

will start making vertebral

vertebral column around it

is that right and there will be of

course are the top central nervous

system and spinal cord developing which

will come there but let me show you the

vertebral body you have not seen this is

vertebral body and this is here is the

spinal cord if you want you can make a

section of spinal cord like this here

right anyway

actually then of course under it there's another

another

and in between the vertebral bodies here

is ah

just please can you tell me intervertebral

intervertebral

disc so you are so intelligent you are

knowing that that there should be interpretable

interpretable

disk here right Amity layer

there is intervertebral disc actually

this intervertebral disc in the very

center of it

it has a special jelly-like material

right jelly-like material and around it

there is fibrous

ring of collagen and all those structures

this jelly-like material which is

present within the

intervertebral disc this jelly-like

structure is called nucleus pulposes

pulposes

right in this diagram I can show nucleus

purposes like this

right and around it of course these are

this nucleus proposes is the remnants of

the local chords

these nucleus purposes are

representative of the remnants of the Noto

Noto

card right

so what we have learned up to now that

how the bile laminar disc convert into

trilominar disc with notochard and

well-defined recoidal plate with

buckofengel membrane spherically and

colloquial plate

quarterly is that right now

another thing

I'll make another diagram here

here was your extra

of course what is this pre-cardial plate

local plate primitive

primitive primitive

primitive node

node

primitive in the center of primitive

node there is primitive State and

primitive streak in the center as

there's a hypoplast hundred which will

disappear and that will be replaced by endo

endo the

the

wizard so

we can say all this process ended up

in formation of

ectoderm which is the remaining part of

the epiblast mesoderm which is between

the acronym and endoderm and the

endoderm is that right and for this

process the conversion of bioluminous

disk into trilominate disc what were the

steps and of course we should not forget

what was the structure here

of course initially there was formation

of notocardial process and then pneuto

chordal plate and then neutral chordal

definitive motor card right now

we'll go step by step right I will show

you with my hand you want to see with my

hands or you want to see the diagram yes

yes

okay you are don't you come here yes I

will show it on your hands

now you stand here the only sad part is

that we are going to show the

development with the hands of the Julio

but it's very unnatural whatever Julio

does he can never make a baby but still

try with his hands yes you make buy

lemonade disc like this okay first this

is the bilateral disc right now listen

carefully we'll show it in this

direction to the camera so that people

can enjoy your beautiful baby

development look this layer upper hand

what is this

let's keep it Loose I'm not going to

take it you're away your hand what is this

this

epiblast and what is this

hypoblast in the beginning and they're

put together so at the end of the second

week there is epiblast and there is

hyperblast and epiblast and hypoblast

both are making what

by eliminators and here is at the top

and this space is

amniotic cavity and Below what is this

definition is that right now we are

going to develop the first thing which

should happen is that this is the

spelling part and this is total part the

caudal part only in upper hand take the

upper hand little bit up

will open here and what we have opened

primitive straight and in that there is

primitive Groove and here is primitive

node with the primitive pet is that right

right

nothing sexy right and then he is

getting excited so I must make it clear

so this primitive pad and primitive

streak with the what is that

Groove okay now these are epiblast cells

and these are hyperblast what really

happens that these cells which are at

the margin of the street they start

producing transforming growth factor

eight this transform growth factor eight

start moving on the sides and force the

cells to proliferate and when these cell

the proliferate plus reduce the

expression of each adherent because e

could hearing keeps the self stick held

together or sticky together with each

other when ecard hearing is less cells

become loose and factor 8

growth factor eight forces the cell to

proliferate and migrate so cells from

the side right they start migrating

towards the primitive State when the

cell comes down from here they go down

and they come here and move on the side

laterally look but if you keep it here

the cells move like this okay please

the cells are moving from here like this

from here they will go down please allow

it and then they'll move on the sides

but to be more accurate they will come

like this move down not only they move

laterally but also forward

is that right so in this way when these

cells are coming down they replace the hypoblast

hypoblast

and the new layer which is made there is

now endoderm then more cells will come

in between the endoderm and epiblast and

they will be present here what are these

but there is a thing that at this point

on the very back

epiblast and endoderma cells are

sticking with each other what is this

local plate and in the very entire

spelling area the cells are also sticky

with each other what is this

ricardle plate is that right now

after making the endoderm and mesoderm

at the same time from the Primitive node

cells as a tube are going down and this

tube move from here forward

this tube goes from here and moves

towards the pre-cardial plate when this

tube is moving forward right this is

called notocol process which extends

from primitive pet up to the

three quarter plate it is here then the

floor of this tube and the endoderm they

touch each other and disintegrate then

amniotic fluid from here can go down to

York sac but very soon the remaining

part of the notocordial plate will come

down and fill the Gap in endoderm then

those cells for example this is

endoderminal cordial process has come

down now these cells will proliferate

and then they go up as definitive not

occurred and endoderm complete right in

the end what you will find you will find

and then remaining IP blast which is

called ectoderm you have to remember

that hypoblast eventually disappears

endoderm and mesoderms are derivatives

of epiblast and remaining epiblast

becomes ectoderm so we can say all three

layers are eventually derived from

Apple glass not from your hand they

derived from IP blast right maybe later

on is tomorrow looking his hand maybe

I'll keep on looking at Baby will come

nothing will happen right okay

so Android then

then

and then ectoderm this will become

trilominar disc is that right you

understand it at three point in the

trilominate disk mesoderm cannot become

in between the active and Endo number

one pre chordal plate

clinical plate and the area where

nodochodal process is present with or

notocoidal definitive notochord is

present between the acrodome and

endoderm is that right you know how

eventually baby will be made

okay he really wants to know let me tell

you okay you go I will tell you

because if I make more on your hands you

will get more Disturbed

let me tell you very simply

this is what

this is

ectoderm what is this

mesoderm and what is this

andodon actually with the time we will a

tube is like this is that right

right

this will be converted into a role

you are understanding we have a disc and

disk will become for example this is the

disc you are looking at what is this Android

Android

and then this is ectoderm this disk will

fold like this

and fuse together

suppose this is the desk right

right

what is this component of the disk

endoderm this is a trilometer disk you

understand it

now we'll make it a role how will it

roll this end and this end to put them together

actor

right

you understand what we have done from

flat disk we have made a role right okay

cream rule you can say now in next stage

this is lateral folding going on the

okay well and eventually these two

Anders will fuse they will

fuse right

what is this

measure done

right and of course you should not

forget what was here

in this area Noto

Noto card

card

and here also there should be Noto card

and behind that Central number system of

spinal cord is developing we'll talk

about that later

endo

the an endoderm also fuse here is that right

right

now this is all ectoderm which will

convert into skin

I'm not going into detail I'm telling a

very basic concept this will become your skin

skin

and what is this mesoderm which will

convert into muscles a urogenital system here

here

this is notochord which will develop

around it

Force the development of vertebral

column and also spinal cord and what is this

this

this is developing gastrointestinal

system what are they developing

gastrointestinal so basically body has

body wall

outside ectodermal then mesodermal

derivative and then andro-dermal derivatives

derivatives

is that right and then

you can understand how Auto trial

limited disk we made the structure now

what you do from here you pull out something

you pull out and when you pull out this

endoderm does not come into these extensions

these are your upper lamps

right having the ectodermal scan and

ectoderma nails and hair

right and these are the mesodermal

derivatives like bones and muscles and

ligaments and tendons

right there's no Visa in the arm you

must know

right same legs are derived right and

development of head and neck is bit

complicated I will tell you later the

disc fold on itself like this

right and this Pro chordal plate that I

will talk later

so in this way this is a basic design of

baby that once you have made the three

layers then three layers will actually

fold into

primitive baby structure and then

definitive organ system will start

developing from ectoderm and mesoderm

and endoderm that is why there's so many

questions what are the derivatives of

factoderm what are the derivatives of

mesoderm what are the derivatives of

androdon right so by the end of the

third week and beginning of the fourth

week we have completed the gastrulation

what was gastrulation

a process by which we convert the

biliminal disc into dry laminaridness

gastrulation process has what steps just

to recap gastrulation process has number

one formation of primitive streak and

primitive node

and within the Primitive streak there is

primitive Groove and in the Primitive

node there is primitive

paired and then epiblastic cells move

towards the street and towards the node

and then they go down first they make

endoderm then they make mesoderm right

from the Primitive node nodochordal

process extend forward up to pre-card

will play it right once the trilominant

disk is complete it is having

app remaining Epi blast first of all

endoderm then mesoderm then remaining

Epi blast which is called ectoderm and

notochordal process is that right and

during all this process guest relation

process you have to remember there are

three areas where between the ectoderm

and endoderm mesoderm is not present

number one a precodile plate and

bucopharyngeal membrane

membrane caudally and a notocodal

process extending from

primitive node up to the

up to the ricardial plate is that right

once this gastrulation is completed then

primitive Spirit disappears it has done

its function

remaining development will talk tomorrow

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คำบรรยาย YouTube:development up to 3rd week trileminar disc part 2 360p

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development up to 3rd week trileminar disc part 2 360p