0:05 bone formation also known as
0:09 osteogenesis or oifc is the process by
0:11 which bone tissue replaces embryonic
0:14 connective tissue to form the skeleton
0:17 from childhood to early adulthood oifc
0:21 lengthens and thickens bone in addition
0:23 the process of oifc is used throughout
0:26 life to remodel
0:28 bones there are two methods of prenatal
1:09 matrix over a few days osteoblasts
1:12 become osteocytes and calcium and other
1:15 mineral salts are laid down hardening The
1:16 The
1:19 Matrix the bone matrix develops thin
1:23 Columns of bone called tabuli which fuse
1:34 blood and lymphatic vessels grow into
1:37 the surfaces of the newly formed bone
1:39 and develop red bone
1:42 marrow outside of the bone a dense layer
1:44 of connective tissue called the periostium
1:46 periostium
1:49 forms most outer layers of spongy bone
1:52 are eventually replaced by compact bone
2:30 osificante providing the brain with greater
2:41 protection endochondral oifc the
2:44 replacement of cartilage by bone occurs
2:50 skeleton the process begins when
2:53 embryonic mezen Kim condenses forming
2:55 the cartilage model the shape of the
3:02 the model grows within the fetus
3:05 lengthwise growth is attained via
3:08 interstitial growth width is attained
3:16 growth a nutrient artery penetrates the
3:18 perichondrium increasing nutrient
3:19 availability to the
3:23 cells osteogenic cells are stimulated to
3:25 differentiate into
3:28 osteoblasts these cells secrete Matrix
3:30 beneath the parond
3:33 that forms a thin shell of compact bone
3:34 known as the bone
3:38 collar as the parond begins to form bone
3:41 it is now called the
3:44 periostium the bone collar reduces
3:46 diffusion to the cartilage inside the
3:48 model depriving it of
3:51 nutrients capillaries grow into the
3:53 disintegrating cartilage delivering
3:56 osteoblasts the new growth forms a primary
3:58 primary
4:01 osificante tissue will replace most of the
4:07 cartilage osteoblasts deposit bone
4:22 remodeled the cavity fills with
4:29 marrow oifc proceed forming the main
4:40 diaphysis around the time of birth blood
4:43 vessels enter the epiphyses the ends of
5:08 as a result the interior of the
5:10 epiphysis remains
5:13 spongy secondary oifc leaves a thin
5:17 layer of hyolin cartilage covering the
5:20 epiphyses this is known as articular
5:22 cartilage and it reduces the friction
5:25 and shock in bone joints the change to
5:28 the epiphysis also forms the epiphysial
5:31 plate a l of highin cartilage that
